摘要
目的:对硝酸咪康唑搽剂皮肤的刺激性和致敏性进行了动物实验观察。方法:以家兔为模型进行多次给药皮肤刺激实验。以豚鼠为模型观察硝酸咪康唑搽剂的皮肤致敏作用。结果:硝酸咪康唑搽剂多次给药对家兔正常皮肤和损伤皮肤有轻度刺激性,不引起豚鼠出现过敏反应。结论:硝酸咪康唑搽剂在动物外用是相对安全的,这些动物实验结果为临床用药提供实验依据。
Objective: To study the skin irritation and skin allergenic effect of miconazole nitrate liniment. Methods: Multiple dosing skin irritation test was carried out with rabbit model, and skin sensitization experiment was observed with guinea pig. Results: Miconazole nitrate liniment had mild irritation on the normal skin and the wounded skin, and no allergic response was induced in guinea pig. Conclusion: Miconazole nitrate liniment is relatively safe for external use in animals. These animal experimental results provide experimental basis for clinical medication.
出处
《药物资讯》
2019年第1期16-28,共13页
Pharmacy Information
