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趋化素样因子超家族6在乳腺癌组织中的表达及其与临床病理特征和预后的关系 被引量:5

Expression of CMTM6 in breast cancer tissues and its correlation with patients’ clinicopathological characteristics and prognosis
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摘要 目的:探讨趋化素样因子超家族6(chemokine-like factor-like MARVEL transmembrane domain-containing family member 6,CMTM6)在乳腺癌组织中的表达及其与患者临床病理特征和预后的相关性。方法:选用购自芯超公司的136例乳腺癌组织芯片,其中包括42例配对的癌及癌旁组织,用免疫组织化学染色法检测乳腺癌及癌旁组织中CMTM6的表达水平。用配对χ~2检验比较CMTM6在乳腺癌及癌旁组织中的表达差异,用χ~2检验分析乳腺癌组织中CMTM6表达水平与患者临床病理特征的关系,用Kaplan-Meier及Log rank分析CMTM6表达水平与患者生存期的关系,拟合Cox模型评价不同指标对患者预后的影响程度。结果:CMTM6在乳腺癌组织中的表达水平显著高于癌旁组织(P<0.01)。CMTM6的表达与乳腺癌病理分型和HER2阳性相关(P<0.05)。CMTM6高表达组患者的生存期较CMTM6低表达组显著缩短(P<0.05)。乳腺癌病理分型(HR=10.374,95%CI:3.529~30.497,P<0.01)、TNM分期(HR=4.599,95%CI:1.784~11.856,P<0.01)、三阴性乳腺癌(HR=3.370,95%CI:1.055~10.761,P<0.05)和CMTM6高表达(HR=0.195,95%CI:0.073~0.518,P<0.01)均可作为评判乳腺癌患者预后的独立危险因素。结论:CMTM6在乳腺癌组织中高表达,其可作为乳腺癌患者预后评估的危险因素。 Objective: To investigate the expression of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6(CMTM6) in breast cancer tissues and its correlation with clinicopathological features and prognosis of patients. Methods: A total of 136 breast cancer tissue chips(purchased from Superchip Company), including 42 pairs of matched cancer and paracancerous tissues,were used for this study. The expression level of CMTM6 in cancer and paracancerous tissues was detected by immunohistochemistry. The comparison of CMTM6 expression between breast cancer and paracancerous tissues was conducted by paired χ~2 test. The relationship between CMTM6 expression in breast cancer tissues and the clinicopathological characteristics of patients was analyzed by χ~2 test. Kaplan-Meier and Log rank test analyses were used to analyze the relationship between CMTM6 expression and the survival of patients, and Cox model was used to evaluate the effect of different indicators on the prognosis of patients. Results: The expression of CMTM6 in breast cancer tissues was significantly higher than that in paracancerous tissues(P<0.01). The expression of CMTM6 was correlated with pathological type of breast cancer and HER2 positivity(P<0.05). The survival time of patients in CMTM6 high expression group was significantly shorter than that of patients in CMTM6 low expression group(P<0.05). Pathological type(HR=10.374, 95%CI: 3.529-30.497, P<0.01), TNM stage(HR=4.599, 95%CI: 1.784-11.856, P<0.01), triple-negative breast cancer(HR=3.370, 95%CI: 1.055-10.761, P<0.05) and high expression of CMTM6(HR=0.195, 95%CI: 0.073-0.518, P<0.01) were independent risk factors for prognosis of breast cancer patients. Conclusion:CMTM6 is highly expressed in breast cancer tissues, which can be used as a risk factor for prognosis evaluation of breast cancer patients.
作者 杨小骏 韦俐 郑晓 徐斌 王琦 刘颖婷 张大川 蒋敬庭 YANG Xiaojun;WEI Li;ZHENG Xiao;XU Bin;WANG Qi;LIU Yingting;ZHANG Dachuan;JIANG Jingting(Department of Tumor Biological Treatment&Research Center of Tumor Immunotherapy Engineering Technology in Jiangsu Province&Institute of Cell Therapy,Soochow Universitythe Third Affiliated Hospital of Soochow University,Changzhou 213003,Jiangsu,China;Department of Pathology,the Third Affiliated Hospital of Soochow University,Changzhou 213003,Jiangsu,China)
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2020年第4期391-395,共5页 Chinese Journal of Cancer Biotherapy
基金 国家重点研发计划资助项目(No.2018YFC1313400) 国家科技支撑计划(No.2015BAI12B12) 海外及港澳学者合作研究基金项目(No.31729001) 国家自然科学基金资助项目(No.31570877,No.31570908) 江苏省重点研发计划(No.BE2018645)。
关键词 乳腺癌 趋化素样因子超家族6 组织芯片 预后 breast cancer chemokine-like factor-like MARVEL transmembrane domain-containing family member 6(CMTM6) tissue chip prognosis
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