摘要
目的:分析鼻咽癌调强放疗患者放射性口腔黏膜炎相关因素。方法:选取我院在2017年1月至2019年2月期间收治的120例鼻咽癌调强放疗患者,严密监测患者放疗期间口腔黏膜变化,每日观察患者用药、口腔pH值、营养、吸烟、口腔卫生等14项指标,各因素使用Lpgistic回归分析。结果:120例鼻咽癌患者调强放疗期间放射性口腔黏膜发生率为100%,轻度占28.33%,重度占71.67%;多因素Logistic回归分析,吸烟、口腔护理、口腔pH值、抗生素使用、化疗是导致放射性口腔炎的独立危险因素。结论:鼻咽癌调强放疗患者具较高的放射性口腔黏膜炎发生率,吸烟史、口腔护理低、同步化疗、未使用抗生素是致放射性口腔黏膜炎的重要危险因素,临床应高度重视,采取针对性干预措施。
Objective:To analyze the related factors of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiotherapy(IMRT).Methods:120 patients with nasopharyngeal carcinoma treated by intensity modulated radiotherapy in our hospital from January 2017 to February 2019 were selected.Oral mucosal changes were closely monitored during radiotherapy.14 indexes such as medication,oral pH value,nutrition,smoking and oral hygiene were observed daily.All factors were analyzed by Lpgistic regression analysis.Results:The incidence of radiation-induced oral mucosa in 120 patients with nasopharyngeal carcinoma was 100%,mild 28.33%and severe 71.67%.Multivariate logistic regression analysis showed that smoking,oral nursing,oral pH value,antibiotic use and chemotherapy were independent risk factors for radiation-induced stomatitis.Conclusion:The incidence of radiation-induced oral mucositis is high in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.Smoking history,low oral care,concurrent chemotherapy and non-use of antibiotics are important risk factors for radiation-induced oral mucositis.Clinical attention should be paid to and targeted interventions should be taken.
作者
庞苏红
衣玉丽
PANG Su-hong;YI Yu-li(Nursing School of Nanchang University,Nanchang Jiangxi 330100,China)
出处
《药品评价》
CAS
2020年第2期59-60,62,共3页
Drug Evaluation
关键词
鼻咽癌
调强放疗
放射性口腔黏膜炎
相关因素
Nasopharyngeal Carcinoma
Intensity Modulated Radiotherapy
Radiation Oral Mucositis
Related Factors
