摘要
目的调查中国北京有关人群高尿酸血症与非酒精性脂肪肝(NAFLD)的相关性。方法选择2017年7月~2018年5月在北京市通州区潞河医院体检中心进行健康体检的6750名人群作为研究对象。收集的指标包括人群的基本资料及相应的生化指标和腹部彩超等。比较高尿酸血症者和非高尿酸血症者的基本资料、生化指标及代谢综合征和脂肪肝发生率,根据文献将血尿酸水平四分位数分层,利用二元logistic回归控制多重混杂因素后分析高尿酸血症是否是NAFLD的独立危险因素。结果男性中,高尿酸血症患者体重、体重指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、肌酐(Scr)较非高尿酸血症水平升高(P<0.05),而高密度脂蛋白胆固醇(HDL-C)水平下降(P<0.05)。女性中,高尿酸血症患者体重、BMI、丙氨酸氨基转移酶、天冬氨酰氨基酸转移酶、TG、TC、LDL-C、Scr较非高尿酸血症水平升高(P<0.05),而HDL-C水平下降(P<0.05)。无论男女高尿酸血症患者NAFLD发病率和代谢综合征都较非高尿酸血症高(P<0.05);经过多种混杂因素矫正,血尿酸每增加50μmol/L,女性NAFLD的发生风险增加11.2%(P<0.05);将血尿酸水平按照四分位数进行分层后,经过多种混杂因素矫正,采用logistic回归方法发现随着血尿酸水平的增加NAFLD的发生风险逐渐增高(以血尿酸≤270μmol/L作为参照),其血尿酸271~320μmol/L人群,NAFLD发生风险为1.258倍(95%CI:1.012~1.563);血尿酸321~379μmol/L人群,NAFLD发生风险为1.523倍(95%CI:1.226~1.892);血尿酸≥380μmol/L人群,发生风险为1.696倍(95%CI:1.338~2.148),血尿酸与NAFLD呈正相关,是发生NAFLD的独立危险因素,而男性没有此相关性。结论血尿酸是NAFLD的独立危险因素,并且具有性别差异性,女性较男性更具有相关性。
Objective To investigate the association between hyperuricemia and nonalcoholic fatty liver(NAFLD)in Beijing of China.Methods A total of 6750 participants who enrolled in the physical examination from July 2017 to May 2018 at the Health Checkup Center of Luhe Hospital in Tongzhou District,Beijing.The data included the basic information of the population and the corresponding biochemical indicators and abdominal color ultrasound.The differences in the basic data,biochemical indicators,metabolic syndrome,and the incidence of fatty liver between hyperuricemia and non-hyperuricemia were compared.According to the literature,the quartiles of serum uric acid level were analyzed and whether hyperuricemia was an independent risk factor for NAFLD after controlling for multiple confounders using binary logistic regression.Results In men,the body weight,body mass index(BMI),total cholesterol(TC),low density lipoprotein cholesterol(HDL-C)and creatinin(Scr)of patients with hyperuricemia were higher than those without hyperuricemia(P<0.05),while the high density lipoprotein cholesterol(HDL-C)level was lower(P<0.05).In women with hyperuricemia,weight,BMI,alanine aminotransferase,asparagine aminotransferase,TG,TC,LDL-C,and Scr were higher than those without hyperuricemia(P<0.05),while HDL-C levels were lower(P<0.05).The incidence of NAFLD and metabolic syndrome in both men and women with hyperuricemia was higher than that of non-hyperuricemia(P<0.05).After correction for various confounding factors,for every 50 mol/L increase in serum uric acid,the risk of occurrence of NAFLD increased by 11.2%(P<0.05).After stratifying uric acid levels according to quartile,logistic regression was used to find that the risk of nonalcoholic fatty liver increased with the increase of serum uric acid level after multiple confounding factors were corrected(blood uric acid≤270μmol/L as a reference),the blood uric acid in 271-320μmol/L crowd their risk of the occurrence of NAFLD was 1.258 times(95%CI:1.012-1.563),blood uric acid in 321-379μmol/L,
作者
张媛媛
杨龙艳
王岩
孙荣欣
付颖
赵冬
ZHANG Yuanyuan;YANG Longyan;WANG Yan;SUN Rongxin;FU Ying;ZHAO Dong(Endocrine Metabolism and Immunization Center,Luhe Hospital,Capital Medical University,Beijing 101149,China)
出处
《中国医药导报》
CAS
2020年第11期111-115,共5页
China Medical Herald
基金
北京市自然科学基金资助项目(7194282)
北京市通州区科委科技创新专项项目(KJ2019CX014-22)。
关键词
非酒精性脂肪肝
高尿酸血症
性别差异
相关性研究
发生风险
Nonalcoholic fatty liver
Hyperuricemia
Gender differences
Correlation studies
Occurrence risk
