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心肌梗死后GDF-15表达与左室重构的相关性研究 被引量:9

Correlation between GDF-15 expression and left ventricular remodeling after myocardial infarction
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摘要 目的探讨心肌梗死后GDF-15表达与左室重构的相关性。方法选取2018年1月~2019年5月包头医学院第一附属医院(以下简称“我院”)收治的急性心肌梗死患者50例为研究组,选择同期来我院体检中心进行体检的老年健康人群50名作为对照组。收集两组临床资料,比较两组血清N末端B型钠尿肽原(NT-proBNP)、生长分化因子-15(GDF-15)水平及左室重构相关指标值。按照NYHA分级、心衰分期将研究组分别分为4个亚组,比较各亚组NT-proBNP、GDF-15、左室质量指数(LVMI)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)水平。相关性分析采用Pearson相关分析,诊断效能评价采用ROC曲线分析。结果研究组NT-proBNP、GDF-15、LVEDD、LVMI水平均明显高于对照组,LVEF水平明显低于对照组(均P<0.01)。NYHA分级越高,NT-proBNP、GDF-15、LVEDD、LVMI水平越高,LVEF水平越低(均P<0.05)。心衰分期越高,NT-proBNP、GDF-15、LVMI水平越高(均P<0.05)。血清GDF-15水平与LVEF水平呈负相关(r=-0.421,P<0.001),与NT-proBNP、LVEDD、LVMI水平呈正相关(r=0.424,0.478,0.396;P<0.001)。NT-proBNP曲线下面积为0.789,最佳分界点为199.45 pg/mL;GDF-15曲线下面积为0.796,最佳分界点为144.36 pg/mL。结论血清GDF-15与左室重构密切相关,随心衰分期及心功能分级的增加而升高,对左室重构的诊断价值与NT-proBNP基本相当。 Objective To investigate the correlation between GDF-15 and left ventricular remodeling after myocardial infarction.Methods From January 2018 to May 2019,50 cases with acute myocardial infarction who admitted to the First Affiliated Hospital of Baotou Medical College(“our hospital”for short)were selected as the study group.50 elderly healthy people who came to physical examination center of our hospital for physical examination during the same period were selected as the control group.Clinical data of two groups were collected,and the level of N-terminal pro-brain B-type natriuretic peptides(NT-proBNP),growth differentiation factors-15(GDF-15)and left ventricular remodeling correlation index value were compared.According to NYHA classification and heart failure stage,the study group was divided into 4 subgroups respectively,NT-proBNP,GDF-15,left ventricular mass index(LVMI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)levels of two groups were compared.Pearson correlation analysis was used for correlation analysis,and ROC curve analysis was used for diagnostic efficacy evaluation.Results NT-proBNP,GDF-15,LVEDD and LVMI levels of the study group were significantly higher than those of the control group,while LVEF values were significantly lower than those of the control group(P<0.01).The higher the NYHA classification,the higher the levels of NT-proBNP,GDF-15,LVEDD and LVMI,and the lower the levels of LVEF(all P<0.05).The higher the heart failure stage,the higher the levels of NT-proBNP,GDF-15 and LVMI(all P<0.05).Serum GDF-15 level was negatively correlated with LVEF(r=-0.421,P<0.001)and positively correlated with NT-proBNP,LVEDD and LVMI(r=0.424,0.478,0.396;P<0.001).The area under NT-proBNP curve was 0.789,and the optimal cut-off point was 199.45 pg/mL.The area under the curve of GDF-15 was 0.796,and the optimal cut-off point was 144.36 pg/mL.Conclusion Serum GDF-15 is closely related to left ventricular remodeling and increases with the increase of heart failure sta
作者 张晓君 张昕 李莉 秦瑞丽 于永玲 ZHANG Xiaojun;ZHANG Xin;LI Li;QIN Ruili;YU Yongling(Department of Cardiac Function,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia Autonomous Region,Baotou 014010,China)
出处 《中国医药导报》 CAS 2020年第11期57-60,共4页 China Medical Herald
基金 包头医学院科学研究基金青苗计划(BYJJ-QM-2018015)。
关键词 心肌梗死 N末端B型钠尿肽原 生长分化因子-15 彩色多普勒超声 左室重构 Myocardial infarction N-terminal pro-brain B-type natriuretic peptides Growth differentiation factors-15 Color doppler ultrasound Left ventricular remodeling
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