摘要
目的对丙种球蛋白联合甲基强的松龙治疗小儿重症病毒性脑炎的效果进行研究。方法选择该院儿科收治的40例小儿病毒性脑炎患儿作为该次研究的纳入对象,选取时间段为2018年1月-2019年2月。按照患儿的病历单双号将其划分为地塞米松治疗组和联合用药组,每组20例。采用地塞米松对地塞米松治疗组予以治疗,采用丙种球蛋白联合甲基强的松龙对联合用药组予以治疗。在治疗完成之后,分析并且比较两组患儿的治疗效果。结果在总有效率方面,地塞米松治疗组共计达到了70.0%,联合用药组共计达到了95.0%。联合用药组明显高于地塞米松治疗组,经过检验,数据差异有统计学意义(χ^2=21.351,P<0.05)。在症状消失时间方面,地塞米松治疗组意识障碍消失时间为(6.6±0.6)d,抽搐消失时间为(3.1±0.7)d,脑膜刺激征消失时间为(5.7±1.6)d,发热消失时间为(6.7±0.8)d;联合用药组意识障碍消失时间为(5.1±0.3)d,抽搐消失时间为(2.1±0.4)d,脑膜刺激征消失时间为(4.3±1.4)d,发热消失时间为(4.2±0.3)d。联合用药组的各种症状消失时间均明显少于地塞米松治疗组,经过检验,数据差异有统计学意义(t=3.458、3.017、3.055、2.429,P<0.05)。结论在小儿重症病毒性脑炎的临床治疗中应用丙种球蛋白联合甲基强的松龙效果确切,不仅疗效显著,还能够使患儿的临床症状在较短的时间内得到有效改善。
Objective To study the effect of gamma globulin combined with methylprednisolone in the treatment of severe viral encephalitis in children. Methods Forty children with viral encephalitis admitted to the hospital were enrolled as subjects of this study. The time period was from January 2018 to February 2019. According to the patient’s medical record, the patient was divided into the dexamethasone treatment group and the combination medication group,with 20 cases in each group. The dexamethasone treatment group was treated with dexamethasone, and the combination group was treated with gamma globulin combined with methylprednisolone. After the treatment was completed, the therapeutic effects of the two groups of children were analyzed and compared. Results In terms of total effective rate, the total dexamethasone treatment group reached 70.0%, and the combined medication group reached 95.0%. The combination group was significantly higher than the dexamethasone group, and the data were significantly different(P<0.05). In terms of symptom disappearance time, the disappearance time of consciousness disorder in dexamethasone treatment group was(6.6±0.6)d, the time of convulsion disappearance was(3.1±0.7)d, and the disappearance time of meningeal irritation sign was(5.7±1.6)d,fever disappearance time(6.7±0.8)d;the disappearance time of consciousness disorder in the combination group was(5.1±0.3)d, the time of disappearance of convulsion was(2.1±0.4)d, and the disappearance time of meningeal irritation was(4.3±1.4)d,fever disappearance time(4.2±0.3)d. The disappearance time of various symptoms in the combination group was significantly lower than that in the dexamethasone treatment group. After testing, the data were statistically significantly different(t =3.458,3.017,3.055,2.429,P <0.05). Conclusion The application of gamma globulin combined with methylprednisolone in the clinical treatment of severe viral encephalitis in children is effective,not only has significant curative effect, but also can effectively
作者
王岩
WANG Yan(Department of Pediatrics,Guanxian Central Hospital,Guanxian,Shandong Province,252500 China)
出处
《系统医学》
2020年第3期102-104,共3页
Systems Medicine
关键词
丙种球蛋
甲基强的松龙
小儿
重症病毒性脑炎
效果
症状
Gamma globule
Methylprednisolone
Pediatric
Severe viral encephalitis
Effect
Symptoms
