摘要
目的分析重症病毒性脑炎患儿使用丙种球蛋白联合甲泼尼龙琥珀酸钠治疗的效果。方法选取2021年11月—2023年7月吉林市儿童医院收治的86例重症病毒性脑炎患儿为研究对象,随机数表法分为两组,各43例。常规组采用地塞米松治疗,研究组在常规组的基础上加用丙种球蛋白联合甲泼尼龙琥珀酸钠治疗,比较两组治疗效果。结果研究组治疗有效率为93.02%,高于常规组的74.42%,差异有统计学意义(χ^(2)=5.460,P=0.019)。研究组抽搐、发热、意识障碍、脑膜刺激征、颅内刺激征等症状改善时间、住院时间均短于常规组,差异有统计学意义(P均<0.05)。研究组神经功能缺损评分、神经生长因子和神经元特异性烯醇化酶水平均优于常规组,差异有统计学意义(P均<0.05)。研究组白细胞介素-6、γ-干扰素水平均优于常规组,差异有统计学意义(P均<0.05)。结论为重症病毒性脑炎患儿使用丙种球蛋白联合甲泼尼龙琥珀酸钠进行治疗,可以改善患儿神经功能,能够降低患儿炎性反应,疗效显著。
Objective To analyze the effect of treatment of severe viral encephalitis in children with gamma globulin combined with methylprednisolone sodium succinate.Methods A total of 86 children with severe viral encephalitis treated in Jilin City Children's Hospital from November 2021 to July 2023 were selected as the study objects and were divided into two groups according to the random number table method with 43 cases in each group.The conventional group was treated with dexamethasone,and the study group was treated with gamma globulin combined with methylprednisolone sodium succinate on the basis of the conventional group,and the therapeutic effect of the two groups was compared.Results The effective rate of the study group was 93.02%,which was higher than that of the conventional group(74.42%),and the difference was statistically significant(χ^(2)=5.460,P=0.019).The improvement time of symptoms such as convulsion,fever,disturbance of consciousness,meningeal irritation and intracranial irritation in the study group were shorter than that in the conventional group,and the differences were statistically significant(all P<0.05).The nerve function deficit score,the levels of the nerve growth factor and neuron specific enolase in the study group were better than those in the conventional group,and the differences were statistically significant(all P<0.05).The levels of interleukin-6 andγ-interferon in the study group were better than those in the conventional group,and the differences were statistically significant(both P<0.05).Conclusion For children with severe viral encephalitis,the use of gamma globulin combined with methylprednisolone sodium succinate for treatment can improve the neurological function of the children,and can reduce the inflammatory reaction of the children,with remarkable therapeutic efficacy.
作者
韩瑾
徐雅
邱卓
HAN Jin;XU Ya;QIU Zhuo(Third Therapeutic Area,Jilin Children's Hospital,Jilin,Jilin Province,132012 China;Ninth Therapeutic Area,Jilin Children's Hospital,Jilin,Jilin Province,132012 China;Rehabilitation Department,Jilin Children's Hospital,Jilin,Jilin Province,132012 China)
出处
《系统医学》
2024年第6期21-24,共4页
Systems Medicine
关键词
重症
病毒性脑炎
丙种球蛋白
甲泼尼龙琥珀酸钠
Severe
Viral encephalitis
Gamma globulin
Methylprednisolone sodium succinate
