摘要
目的分析阿昔洛韦联合人免疫球蛋白病毒性脑炎患儿的治疗效果。方法单纯随机选取2022年6月—2023年6月泉州市第一医院儿科收治的90例病毒性脑炎患儿作为研究对象,按照随机数表法分为两组,各45例,对照组应用阿昔洛韦干预,观察组应用阿昔洛韦联合人免疫球蛋白干预,对比两组各项指标的恢复情况、炎性因子的水平和临床效果、治疗有效率、不良反应发生率。结果观察组患儿症状恢复时间短于对照组,差异有统计学意义(P<0.05)。治疗前两组血清炎症因子、脑脊液炎症因子比较,差异无统计学意义(P均>0.05);治疗后观察组血清炎症因子、脑脊液炎症因子优于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为2.22%,低于对照组的13.33%,差异有统计学意义(χ^(2)=3.873,P<0.05)。观察组治疗总有效率为97.78%,高于对照组的86.67%,差异有统计学意义(χ^(2)=3.873,P<0.05)。结论对病毒性脑炎的患儿应用阿昔洛韦联合人免疫球蛋白静注治疗有利于促进患儿的康复,减轻患儿的炎症反应,控制病情,修复神经,降低并发症发生率,促进病情转归。
Objective To analyze the therapeutic effect of acyclovir combined with human immunoglobulin virus encephalitis in children.Methods A total of 90 children with viral encephalitis admitted to the Department of Pediatrics of Quanzhou First Hospital from June 2022 to June 2023 were randomly selected as the study objects.They were divided into two groups with 45 cases in each group by random number table method.The control group was treated with acyclovir intervention,and the observation group was treated with acyclovir combined with human immunoglobulin intervention.The recovery of various indexes,the level of inflammatory factors and clinical effects,the treatment effectiveness,the incidence of adverse reactions of the two groups were compared.Results The recovery time of symptoms in observation group was shorter than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in serum inflammatory factors and cerebrospinal fluid inflammatory factors between the two groups before treatment(both P>0.05).After treatment,the serum inflammatory factors and cerebrospinal fluid inflammatory factors in the observation group were better than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in the observation group was 2.22%,lower than that in the control group(13.33%),and the difference was statistically significant(χ^(2)=3.873,P<0.05).The total effective rate of the observation group was 97.78%,higher than that of the control group(86.67%),and the difference was statistically significant(χ^(2)=3.873,P<0.05).Conclusion The application of acyclovir combined with human immunoglobulin in the treatment of viral encephalitis in children is beneficial to promote the recovery of children,reduce the inflammatory response of children,control the disease,repair the nerve,reduce the incidence of complications,and promote the prognosis of the disease.
作者
陈婷婷
许白叶
CHEN Tingting;XU Baiye(Department of Pediatrics,Quanzhou First Hospital,Quanzhou,Fujian Province,362000 China)
出处
《中外医疗》
2024年第12期89-92,共4页
China & Foreign Medical Treatment
关键词
阿昔洛韦
人免疫球蛋白静注
病毒性脑炎
Acyclovir
Intravenous infusion of human immunoglobulin
Viral encephalitis
