摘要
探讨泪道扩张引流管植入联合中药熏蒸对慢性泪囊炎急性发作患者疗效、再次阻塞、不良反应的影响。选择2016年2月至2018年3月在我院接受治疗的慢性泪囊炎急性发作患者98例进行研究。采用随机数字表法将患者分为2组,每组各49例。对照组行泪道扩张引流管植入治疗,术前术后均根据检查结果全身及局部使用抗生素,观察组手术及术前处理同对照组,术后局部采用中药熏蒸治疗,细菌培养阳性者局部给予抗生素。对比两组患者疗效、发热率、再次阻塞率、生活质量、血清血管内皮生长因子(vascular endothelial growth factor,VEGF)及降钙素元(procalcitonin,PCT)及不良反应发生情况。对照组好转率为83.67%,显著低于观察组的95.92%(P<0.05)。对照组术后1周发热率为8.16%,与观察组的4.08%差异无统计学意义(P>0.05)。对照组再次阻塞率为18.37%,显著高于观察组的4.08%(P<0.05)。两组患者干预后生活质量得分均明显升高,但观察组患者升高幅度显著高于对照组(P<0.05)。两组患者干预后VEGF及PCT均明显下降,但观察组下降幅度更为明显(P<0.05)。两组患者肝肾功能、血常规、尿常规及大便常规治疗期间均未出现明显异常,且两组均未出现明显不良反应。泪道扩张引流管植入联合中药熏蒸治疗慢性泪囊炎急性发作可明显提高疗效、降低再次阻塞率,不增加术后1周发热率及不良反应发生率。
To investigate the effect of lacrimal duct dilation drainage tube implantation combined with traditional Chinese medicine fumigation on the curative effect,re-occlusion,and adverse reactions in patients with acute episode of chronic dacryocystitis.A total of ninety-eight patients with acute episodes of chronic dacryocystitis who were treated in our hospital from February 2016 to March 2018 were selected for study.The control group was treated with lacrimal duct dilation and drainage tube implantation and the observation group was treated with lacrimal duct dilatation drainage tube combined with traditional Chinese medicine fumigation.Before and after surgery,antibiotics were used systemically and locally according to the examination results.The efficacy,fever rate,reocclusion rate,quality of life,serum vascular endothelial growth factor(VEGF),procalcitonin(PCT)and adverse reactions were compared between the two groups.The improvement rate of the control group was 83.67%,significantly lower than that of the observation group of 95.92%(P<0.05).The fever rate in the control group after one week was 8.16%,but it was not statistically different from the observation group's 4.08%(P>0.05).The reocclusion rate of the control group was 18.37%,which was significantly higher than that of the observation group(4.08%)(P<0.05).The quality of life scores of two groups of patients were significantly increased after intervention.The increasing amplitude in the observation group was significantly higher than that in the control group(P<0.05).VEGF and PCT decreased significantly after intervention in both groups,but the decreasing amplitude in the observation group was more significant(P<0.05).There were no obvious abnormalities in liver and kidney function,blood routine,urine routine and stool routine treatment in both groups,and no obvious adverse reactions occurred in both groups.Lacrimal duct dilation drainage tube implantation combined with traditional Chinese medicine fumigation for the acute attack of chronic dacryocystitis
作者
李建良
梁瑞娟
王蓉
杜红彦
骆煌
简月玲
蔡金英
LI Jian-liang;LIANG Rui-juan;WANG Rong;DU Hong-yan;LUO huang;JANE Yue-ling;CAI Jin-ying(Guangzhou Traditional Chinese Medicine Hospital, Guangzhou 510130, China;Sun Yixian Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China)
出处
《广西大学学报（自然科学版）》
CAS
北大核心
2020年第2期427-432,共6页
Journal of Guangxi University（Natural Science Edition）
基金
国家自然科学基金资助项目(81704123)。
关键词
泪道扩张引流管
中药熏蒸
慢性泪囊炎急性发作
疗效
再次阻塞
Lacrimal duct dilatation drainage tube
Fumigation of traditional Chinese medicine
Acute attack of chronic dacryocystitis
curative effect
blocked again
