摘要
目的分析新型布尼亚病毒感染致发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)患者的临床实验室资料,重点比较重症不同预后患者的实验室指标差异,为早期预测疾病预后提供理论依据。方法调查两所医院2011年1月-2018年12月收治的所有确诊患者的临床实验室指标,并对数据作统计学分析。结果研究共纳入确诊研究对象168例,其中非重症117例,重症51例;重症患者预后好转30例,预后不良21例。对重症不同预后患者实验室检查指标进行比较分析,发现多项指标有统计学差异。此外,预后不良重症患者昏迷、弥漫性血管内凝血、心力衰竭等临床症状比例高于预后好转的重症患者(均有P<0.05)。结论针对可能发生预后不良的重症患者制定差异化的防治方案。
Objective To analyze the clinical laboratory indicators of severe fever with thrombocytopenia syndrome(SFTS)patients caused by novel Bunyavirus infection,and focus on comparing the indicators of severe patients with different prognosis.The findings may help to predict poor prognosis for severe patients in the early stage.Methods The clinical laboratory indicators of all diagnosed confirmedly patients in two Hospitals,from January 2011 to December 2018,and the differences between groups were analyzed.Results A total of 168 clinically diagnosed SFTS cases(117 cases of non-severe cases and 51 cases of severe cases)were included in this study.In the severe cases,the prognosis was improved in 30 cases and the prognosis was poor in 21 cases.The laboratory indicators of severe patients with different prognosis were compared.The data showed that the levels of several indicators in patients with poor prognosis were statistically different with these in patients with better prognosis.In addition,the proportion of coma,diffuse intravascular coagulation and heart failure in patients with poor prognosis was significantly higher than that in patients with improved prognosis(all P<0.05).Conclusion Differentiated prevention and treatment strategies should be developed for severe patients with possible poor prognosis.
作者
张鸿雁
陈桂榴
李文庭
冷瑞雪
秦薇子
ZHANG Hong-yan;CHEN Gui-liu;LI Wen-ting;LENG Rui-xue;QIN Wei-zi(Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,China;Propaganda Department of Party Committee,Chaohu Hospital of Anhui Medical University,Hefei 238000,China;Department of Prevention and Health Protection,The First Affiliated Hospital of USTC,Hefei 230001,China;Department of Infectious Diseases,The First Affiliated Hospital of USTC,Hefei 230001,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2020年第3期365-368,共4页
Chinese Journal of Disease Control & Prevention
基金
安徽省重点研究与开发计划(1704e1002231)。
关键词
发热伴血小板减少综合征
新型布尼亚病毒
临床实验室指标
重症
预后
Severe fever with thrombocytopenia syndrome
Novel Bunyavirus infections
Clinical laboratory features
Severe disease
Prognosis
