摘要
发热伴血小板减少综合征(SFTS)是近年来在我国部分地区相继出现的感染性疾病,2009年在中国大陆首次被发现,近年来已在大半个中国流行并传播,在韩国、日本和美国也陆续有类似疫情报道,已致数千人患病甚至死亡;该病以发热、血小板减少和多脏器功能损害为主要临床表现,死亡率达10%。目前已经证实其由发热伴血小板减少综合征布尼亚病毒(SFTSV)感染所致。SFTSV的基因组由大(L)、中(M)、小(S)3个单股负链RNA片段组成。为更详细地了解SFTSV,本文针对其病原学特征、流行病学特征以及疾病预防等方面对近年来的有关研究进行了整理和综述,以期为发热伴血小板减少综合征(SFTS)的预防和治疗提供理论依据。
Severe fever with thrombocytopenia syndrome(SFTS)is an infectious disease that has occurred in some regions of China in recent years.SFTS was firstly described in China in 2009,followed by several reports from other countries worldwide,such as South Korea,Japan and the USA.SFTSV epidemic undergoes rapidly through China in recent years.Thousands of people were infected with an average fatality rate.With fever,thrombocytopenia,and multiple organ dysfunction as the main clinical manifestations,the patients with SFTS had a fatality rate up to 10%.SFTS bunyavirus(SFTSV)has been identified as the causative pathogen of SFTS.The genome of the virus consists of three(large,medium and small)single stranded negative RNA chains.This review focused on the pathogenicity,prevalence and detection of SFTSV infection to update the current understanding about early diagnosis and prevention of SFTS.
作者
李青
LI Qing(Anhui Center for Disease Control and Prevention,Hefei,Anhui 230601,China)
出处
《中国热带医学》
CAS
2019年第10期1004-1008,共5页
China Tropical Medicine
基金
全国重点传染病及病媒生物监测项目(No.2014-36-W-496)
