摘要
目的了解安徽省巢湖地区新布尼亚病毒感染患者的临床特点和病重相关危险因素。方法回顾性分析2012年4月~2015年11月安徽医科大学附属巢湖医院确诊的发热伴血小板减少综合征布尼亚病毒(severe fever with thrombocytopenia syndrome bunyavirus,SFTSV)(简称"新布尼亚病毒")感染住院病例,采用描述流行病学方法对确诊的病例流行特征、临床特点进行分析,并用单因素Logistic回归分析与病情严重程度相关危险因素。结果安徽省巢湖地区2012-2015年共报告57例发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS),病死率为19.3%,且该地区SFTSV感染的病例呈逐年上升趋势,而农民及高龄是重症组的高危因素;4~9月为该病流行季,发病月份主要集中在5~6月份;经单因素Logistic回归分析,发现意识障碍(OR=14.236,95%CI:1.324~152.091)、血尿(OR=2.583,95%CI:1.114~5.990)和空腹葡萄糖升高(OR=34.838,95%CI:2.113~569.427)对病情严重程度具有预测作用。结论患者一旦出现意识障碍、血尿及空腹葡萄糖升高时,提示其病情危重,应引起医护人员的足够重视。
Objective To investigate the epidemiological features and clinical characteristics of the new Bunyavirus infection in Chaohu Area. Methods We reviewed and analyzed the hospitalized diagnosed cases with severe fever with thrombocytopenia syndrome virus（ SFTSV） in Chaohu hospital of Anhui Medical University,from Apr 2012 to Nov 2015.We used descriptive epidemiology method to analyze the epidemiological features,clinical characteristics and influencing factors for the severity of diagnosed cases with SFTSV. Results 57 cases of SFTS were reported during 2012- 2015 and the fatality rate was 19. 3%; The trend of SFTSV infection had been increasing in Chaohu year by year. Farmers and the olds were the most patients infected with SFTSV; It was prevalent from April to September,and patients were most easily attacked in May and June; Disturbance of consciousness（ OR = 14. 236,95% CI： 1. 324-152. 091）,hematuria（ OR =2. 583,95% CI： 1. 114-5. 990） and high levels of fasting glucose（ OR = 34. 838,95% CI： 2. 113-569. 427） could forecast the severity of SFTSV infection by univariate logistic regression model. Conclusions When the patients are in the event of disturbance of consciousness,hematuria,and high levels of fasting glucose,it indicates a critical condition and medical staff should pay sufficient attention to such performance.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第1期56-60,共5页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81571963)
关键词
血小板减少
布尼亚病毒科感染
危险因素
Thrombocytopenia
Bunyaviridae infections
Risk factors
Clinical characteristics
