摘要
随着对胆汁酸的研究不断深入,逐渐发现并证实了高水平胆汁酸可致多种类型的心律失常,例如,窦性心动过缓、心房颤动(AF)、房室传导阻滞等,严重者甚至可出现心脏骤停。还发现胎儿比成人更易发生胆汁酸诱导的心律失常。人们已经认识到胆汁酸可通过多种机制导致心律失常,例如,胆汁酸对离子及离子通道的影响、受体介导、迷走神经介导等途径。而熊去氧胆酸是目前发现的对心脏有保护作用、并且具有抗心律失常效应的胆汁酸。现就胆汁酸致心律失常的作用及其机制进行综述。
With the research advances on bile acid,it has gradually been discovered and confirmed that high levels of bile acids can cause various types of arrhythmias,such as sinus bradycardia,atrial fibrillation(AF),atrioventricular block and even occurrence of cardiac arrest in severe cases.In addition,it has also been found that fetuses are more susceptible to bile acid-induced arrhythmias than adults.It has been recognized that bile acids can cause arrhythmias through a variety of mechanisms,such as the effect of bile acids on ions and ion channels,receptor-mediated,vagal-mediated,and other pathways.Ursodeoxycholic acid(UDCA)is currently found to have protective effect on the heart and has an antiarrhythmic effect.This article mainly reviews the function and mechanism of bile acid in arrhythmia.
作者
闫静静
范慧倩
杨玲
Yan Jingjing;Fan Huiqian;Yang Ling(Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2020年第4期361-364,共4页
Chinese Journal of Hepatology
基金
国家自然科学基金(81974078,81570530、81370550)
湖北省科学技术创新项目(2019ACA133)。
