摘要
目的探讨超高分辨率眼前节OCT在结膜增生性疾病诊断中的应用效果。方法选取2017年1月~2018年12月浙江大学附属第一医院及北仑分院眼科门诊收治的150例(150眼)结膜增生性疾病患者作为研究组。另选同期在我院进行体检的结膜正常者80例(80眼)作为对照组。统计分析超高分辨率眼前节OCT在睑裂斑,翼状胬肉及鳞状上皮瘤等结膜增生性疾病中临床诊断与病理诊断的符合率。观察分析睑裂斑,翼状胬肉及鳞状上皮瘤等结膜增生性疾病的特征性表现。结果150例(150眼)结膜增生患者临床诊断为睑裂斑患者30例(30眼),翼状胬肉患者100例(100眼),以及眼表鳞状细胞瘤的患者20例(20眼)。与病理学诊断相比,UHR-OCT诊断睑裂斑诊断符合率为100.00%(30/30),翼状胬肉诊断符合率100.00%(98/98),眼表鳞状细胞瘤诊断符合率为90.91%(20/22),经统计学处理,差异无统计学意义(P>0.05)。睑裂斑患者图像特征:生长在角巩膜缘处停止,且角膜上未见隆起,与前弹力层间未见高反射信号,与巩膜间未见明显分界。翼状胬肉患者图像特征:结膜上皮厚度轻度增厚,上皮层表现为中等程度的高反射,角膜上皮与前弹力层间表现为较高程度的高反射信号。OSSN患者图像特征:结膜上皮增厚,呈高反射,结膜正常上皮与异常上皮转变突然,无过渡区域,深部组织间上皮内可见瘤变。结论超高分辨率眼前节OCT在结膜增生性疾病的诊断中具有较高的准确性,且影像特征明显,具有广阔的临床应用前景。
Objective To investigate the application effect of ultra-high resolution anterior segment OCT in the diagnosis of conjunctival proliferative diseases.Methods A total of 150 patients(150 eyes)with conjunctival proliferative disease who were admitted to the the outpatient clinic of ophthalmology in the First Affiliated Hospital of Zhejiang University and Beilun Branch from January 2017 to December 2018 were selected as the study group.80 patients(80 eyes)with normal conjunctiva who underwent physical examination during the same period in our hospital were selected as the control group.The coincidence rate of ultra-high resolution anterior segment OCT in clinical diagnosis and pathological diagnosis of conjunctival proliferative diseases such as pinguecula,pterygium and squamous epithelioma was statistically analyzed.The characteristic manifestations of conjunctival proliferative diseases such as pinguecula,pterygium and squamous epithelioma were observed and analyzed.Results 150 patients(150 eyes)with conjunctival hyperplasia were diagnosed as 30 patients with pinguecula(30 eyes),100 patients with pterygium(100 eyes),and 20 patients with squamous epithelioma(20 eyes).Compared with pathological diagnosis,the diagnostic coincidence rate of UHR-OCT in the diagnosis of pinguecula was 100.00%(30/30),the diagnostic coincidence rate of pterygium was 100.00%(98/98),and the diagnostic coincidence rate of squamous epithelioma was 90.91%(20/22).After statistical analysis,the differences were not statistically significant(P>0.05).Image characteristics of patients with pinguecula:Growth stopped at the edge of corneosclera,and no bulge was seen in the cornea.There was no high reflection signal between the front elastic layer and no obvious boundary between the sclera.Image characteristics of patients with pterygium:The conjunctival epithelial thickness was slightly thickened,the epithelial layer was shown moderately high reflection,and the corneal epithelium and the pre-elastic layer was shown a higher degree of high reflection
作者
王颖君
郦惠艳
姜波
吴慧锋
史飞飞
黄连华
WANG Yingjun;LI Huiyan;JIANG Bo;WU Huifeng;SHI Feifei;HUANG Lianhua(Department of Ophthalmology,Beilun Branch,the First Affiliated Hospital of Zhejiang University,Ningbo315800,China;Department of Ophthalmology,the First Affiliated Hospital of Zhejiang University,Hangzhou310003,China)
出处
《中国现代医生》
2020年第7期44-46,50,I0002,共5页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2017KY621)。
关键词
超高分辨率
OCT
结膜增生
睑裂斑
翼状胬肉
眼表鳞状上皮瘤
Ultra-high resolution
OCT
Conjunctival proliferation
Pinguecula
Pterygium
Squamous epithelioma
