摘要
目的研究不同疾病活动度类风湿关节炎(RA)患者的骨流失量及骨代谢指标。方法选取北京西部城区120例RA患者为研究对象,根据患者疾病活动度分为轻度组(14例)、中度组(48例)及重度组(58例)。比较三组患者1、2年后的骨量丢失情况;比较三组患者的骨代谢指标;分析三组患者的骨代谢指标水平与DAS28评分的相关性。结果三组患者1、2年后的骨量丢失发生率比较,重度组均显著高于中度组及轻度组(P<0.05)。重度组的BGP、OPN、BALP、TRACP-5b水平均明显高于中度组及轻度组(P<0.05)。患者的DAS28评分与血清25-(OH)D水平呈负相关,与血清BGP、OPN、BALP、TRACP-5b水平呈正相关(P<0.05)。结论RA患者疾病活动度与骨质疏松的发生密切相关,故应加强对RA的控制,防止骨质疏松的发生。
Objective To research the amount of bone loss and bone metabolic markers in patients with rheumatoid arthritis(RA)of different disease activity.Methods A total of 120 RA patients in the city proper of western Beijing were selected as the study objects,and the patients were divided into mild group(14 cases),moderate group(48 cases)and severe group(58 cases)according to the disease activity.The amount of bone loss in the three groups after 1 and 2 years were compared;the bone metabolism indexes in the three groups were compared;the correlation between the levels of bone metabolism indexes and DAS28 score was analyzed.Results After 1 and 2 years,the incidence of amount of bone loss in the severe group was significantly higher than that in the moderate group and mild group(P<0.05).The levels of BGP,OPN,BALP and TRACP-5b in the severe group were significantly higher than those in the moderate group and mild group(P<0.05).DAS28 score was negatively correlated with serum 25-(OH)D level,while which was positively correlated with serum BGP,OPN,BALP and TRACP-5b levels(P<0.05).Conclusion The disease activity of RA patients is closely related to the occurrence of osteoporosis,so the control of RA should be strengthened to prevent osteoporosis.
作者
庞琳娜
孙聪慧
PANG Lin-na;SUN Cong-hui(Rheumatology Department,Shijingshan Teaching Hospital of Capital Medical University,Beijing Shijingshan Hospital,Beijing 100043,China)
出处
《临床医学研究与实践》
2020年第7期35-36,共2页
Clinical Research and Practice
基金
北京市石景山医院院级科研项目(No.2017-05)。
关键词
类风湿关节炎
骨代谢指标
骨流失量
疾病活动度
rheumatoid arthritis
bone metabolic markers
amount of bone loss
disease activity
