摘要
目的 探讨抗CCP抗体、AKA、抗RA33抗体、6-磷酸葡萄糖异构酶（GPI）、RF等RA特异性血清标志物在不同风湿性疾病中的阳性率及分布情况,明确其在RA诊疗中的应用价值及其在非RA患者中阳性的临床意义.方法 对2011年1月至2013年12月本院门诊及住院5 847例接受5种血清标志物检测的患者临床资料、诊断、检查结果进行回顾性研究,计数资料比较应用x2检验.结果 在5847例确诊风湿性疾病患者中RF、抗CCP抗体、抗RA33抗体、AKA、GPI的阳性率分别为：52.5％（3 069/5 847）、40.1％（2 344/5 847）、12.8％（748/5 847）、12.0％（701/5 847）、50.0％（2 923/5 847）,其中RA组患者阳性率分别为：80.4％ （2 784/3 464）、66.1％（2 290/3 464）、16.1％（556/3 464）、20.0％ （694/3 464）、75.1％（2 602/3 464）,显著高于其他疾病组（P＜0.01）;非RA组患者阳性率分别为：12.0％（286/2 383）、2.2％（54/2 383）、8.0％（191/2 383）、0.4％（10/2 383）、13.6％（323/2 383）.结论 RF、抗CCP抗体、抗RA33抗体、AKA、GPI对RA有重要的诊断价值,但是上述标志物也可出现在其他疾病中,因此在临床诊疗过程需综合分析,避免片面根据血清学检查结果导致误诊,除SS外,抗CCP抗体、抗RA33抗体、RF阳性可能与骨侵蚀相关.
Objective To explore the distribution of anti-cyclic citrullinated peptide （CCP） antibody,anti-keratin antibody （AKA）,anti-RA33 antibody,glucose-6-phosphate isomerase （GPI）,rheumatoid factors （RF） in rheumatic diseases,and to evaluate the association between these distributions and rheumatoid arthritis （RA） in order to clarify its application in the diagnosis of rheumatoid arthritis and its clinical significance in non-seral-positive RA patients.Methods Data were derived from outpatients and inpatients of the department of Integrated Traditional and Western Medicine of Southwest Hospital during January,2011 to December,2013.All patients were tested for these five serological markers.Chi-square test was used to analyze the numerical data.Results Among the 5 847 cases,the positive rates of RF,anti-CCP antibody,anti-RA33 antibody,AKA,GPI were 52.5%（3 069/5 847）,40.1%（2 344/5 847）,12.8%（748/5 847）,12.0%（701/5 847）,50.0%（2 923/5 847）,respectively.The positive rates of the RA patient group [80.4%（2784/3 464）,66.1%（2 290/3 464）,16.1%（556/3 464）,20.0%（694/3 464）,75.1%（2 602/3 464）] were signi-ficantly higher than those of other groups （P〈0.01）.The positive rates of the non-RA patients group were 12.0% （286/2 383）,2.2% （54/2 383）,8.0% （191/2 383）,0.4% （10/2 383）,13.6% （323/2 383） respectively.Conclusion RF,anti-CCP antibody,anti-RA33 antibody,AKA,GPI are of great significance in the diagnosis of RA.However,these serological markers are also found in other diseases.In the clinical diagnosis and treatment process,we should analyze comprehensively the specific conditions of patients in order to avoid misdiagnosis.In addition to Sj（o）gren＆#39;s syndrome,the anti-CCP antibodies,anti-RA33 antibodies,RF may be associated with bone erosion.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2014年第4期267-269,共3页
Chinese Journal of Rheumatology
关键词
关节炎
类风湿
生物学标记
敏感性
特异性
Arthritis,rheumatoid
Biological markers
Specificity
Sensitivity
