摘要
目的研究丹参川芎嗪联合血栓通治疗脑梗死的疗效及对血流动力学的影响。方法223例脑梗死患者,采用随机盲选法分为对照组(88例)与治疗组(135例)。对照组给予血栓通治疗,治疗组在对照组基础上联合丹参川芎嗪治疗。比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、脑卒中患者生专用活质量量表(SS-QOL)评分、血液指标、血流动力学指标及治疗效果。结果治疗后,治疗组NIHSS评分(9.13±0.80)分低于对照组的(16.28±1.21)分,SS-QOL评分(72.31±6.12)分高于对照组的(63.44±4.61)分,差异均有统计学意义(P<0.05)。治疗组总有效率为97.78%高于对照组的78.41%,差异有统计学意义(P<0.05)。治疗后,两组全血高切粘度、血小板聚集率、低密度脂蛋白胆固醇、总胆固醇、全血低切粘度均低于本组治疗前,且治疗组均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组平均动脉压(MAP)、中心静脉压(CVP)、右房压(RAP)、左房压(LAP)、心排出量(CO)、心脏每搏量(SV)、体循环阻力(SVR)、体循环阻力指数(SVRI)均优于本组治疗前,且治疗组SV、SVR、SVRI优于对照组,差异有统计学意义(P<0.05)。结论丹参川芎嗪联合血栓通治疗脑梗死有较好的临床疗效。
Objective To study the efficacy of radix salivae miltiorrhizae and ligustrazine combined with Xueshuantong in the treatment of cerebral infarction and its influence on hemodynamics.Methods A total of 223 cerebral infarction patients were randomly divided into control group(88 cases)and treatment group(135 cases).The control group was treated by Xueshuantong,and the treatment group was treated by radix salivae miltiorrhizae and ligustrazine on the basis of the control group.The National Institutes of Health stroke scale(NIHSS)score,stroke specific quality of life scale(SS-QOL)score,blood index,hemodynamic index before and after treatment,and therapeutic effect were compared between the two groups.Results After treatment,NIHSS score(9.13±0.80)points in the treatment group was lower than(16.28±1.21)points in the control group,and SS-QOL score(72.31±6.12)points was higher than(63.44±4.61)points in the control group,and the difference was statistically significant(P<0.05).The total effective rate 98.78% in the treatment group was higher than 78.41%in the control group,and the difference was statistically significant(P<0.05).After treatment,the whole blood high cut viscosity,platelet aggregation rate,low density lipoprotein cholesterol,total cholesterol,whole blood low cut viscosity level of the two groups were lower than those before treatment of the same group,and the treatment group was lower than the control group.Their difference was statistically significant(P<0.05).After treatment,the mean arterial pressure(MAP),central venous pressure(CVP),right atrial pressure(RAP),left atrial pressure(LAP),cardiac output(CO),cardiac stroke volume(SV),systemic vascular resistance(SVR),systemic vascular resistance index(SVRI)in the two groups were better than those before treatment of the same group,and SV,SVR,SVRI in the treatment group were better than those in the control group.The difference was statistically significant(P<0.05).Conclusion The combination of radix salvia miltiorrhiza and ligustrazine and Xueshuantong sh
作者
张昭君
肖湘凌
ZHANG Zhao-jun;XIAO Xiang-ling(Department of Pharmacy,Chaoyang Kangning Hospital,Chaoyang 122000,China)
出处
《中国现代药物应用》
2020年第7期15-17,共3页
Chinese Journal of Modern Drug Application
关键词
脑梗死
血栓通胶囊
丹参川芎嗪注射液
血液动力学
Cerebral infarction
Xueshuantong capsule
Radix salivae miltiorrhizae and ligustrazine injection
Hemodynamics
