摘要
目的基于真实世界总结丹参川芎嗪注射液在临床中常联合使用的中药和化药类别,为该药的临床使用提供参考。方法对2010年2月10日至2019年6月19日全国24家三级甲等医院信息管理系统(hospital information systom,HIS)中38126例使用丹参川芎嗪注射液患者的中药和化药联合用药类别进行分析。结果该药最常联合使用的2种中药类别前3位依次是:清热解毒剂联合活血化瘀剂、补益剂联合活血化瘀剂、解表剂联合活血化瘀剂;联合使用的3种中药类别前3位依次是:祛痰剂联合解表剂与活血化瘀剂、祛痰剂联合清热解毒剂与活血化瘀剂、解表剂联合清热解毒剂与活血化瘀剂。最常联合使用的2种化药类别前3位依次为:抗凝溶栓及抗血小板药联合抗生素类药、抑酸药联合抗生素类药、电解质平衡调节药联合抗生素类药;最常联合使用的3种化药类别前3位依次为:抑酸药联合抗凝溶栓及抗血小板药与抗生素类药、电解质平衡调节药联合抗凝溶栓及抗血小板药类药与抗生素类药、抑酸药联合电解质平衡调节药与抗生素类药。结论丹参川芎嗪注射液在临床使用中联合用药种类较多,但需注意药物间相互作用,避免不良反应发生。
Objective To summarize the category of combined medication of Danshen Ligustrazine injection in the real world so as to provide reference for clinical use.Methods The category of Chinese medicine and western medicine in 38126 patients treated with Danshen Ligustrazine Injection from 24 tertiary first-class hospitals in China from February 10,2010 to June 19,2019 were analyzed.Results The top three categories of the two Chinese medicines that were most commonly used in combination were listed:clearing heat and detoxifying agent combined with promoting blood circulation.Blood stasis removing agent,nourishing agent combined with activating blood and removing blood stasis agent,anti-surface agent combined with promoting blood circulation and removing stasis agent.The top three categories of the three Chinese medicines that of were listed:expectorant combined with external-relieving agent and bloodactivating and stasis-removing agent,expectorant Combine heat-clearing and detoxifying agent with blood-activating and stasis-removing agent.The top three categories of the two western medicines that were most commonly used in combination were listed:anticoagulant thrombolysis and antiplatelet drugs combined with antibiotics,acid suppressants combined with antibiotics,electrolyte balance regulators combined with antibiotics;the most commonly used combined drugs.The top three categories of the three western medicines that of were listed:acid-suppressing drugs combined with anticoagulation and thrombolysis,antiplatelet drugs and antibiotics,electrolyte balance regulators combined with anticoagulant thrombolysis and antiplatelet drugs and antibiotics,acid-suppressing drugs Combined electrolyte balance regulators and antibiotics.Conclusion Danshen Ligustrazine injection has many types of combined drugs in clinical practice.Clinicians should be alert to adverse drug reactions caused by drug-drug interactions in clinical practice.
作者
张宏伟
黎元元
谢雁鸣
马晓昌
王连心
魏瑞丽
孙粼希
徐鸿燕
庄严
ZHANG Hongwei;LI Yuanyuan;XIE Yanming;MA Xiaochang;WANG Lianxin;WEI Ruili;SUN Linxi;XU Hongyan;ZHUANG Yan(Institute of clinical basic medicine of Chinese medicine,Chinese Academy of traditional Chinese medicine,Beijing 100700,China;Xiyuan Hospital,Chinese Academy of traditional Chinese medicine,Beijing 100091,China;School of statistics,Renmin University of China,Beijing 100872,China;Naval General Hospital of the people's Liberation Army,Beijing 100048,China)
出处
《中国药物警戒》
2022年第8期851-856,共6页
Chinese Journal of Pharmacovigilance
基金
国家自然科学基金资助项目(81973982)
国家重点研发计划(2018YFC1707400)
中央级公益性科研所基本科研业费专项资金资助(Z0737)。
关键词
丹参川芎嗪注射液
真实世界
医院信息管理系统
联合用药类别
Salvia Miltiorrhiza injection
real world
hospital information systom(HIS)
the category of combined medication
