摘要
目的观察丁苯酞注射液、胶囊序贯疗法联合依达拉奉治疗急性进展性脑梗死的效果。方法选择2016年2月至2018年2月收治的急性进展性脑梗死患者120例,按照随机数字表法分为观察组和对照组,各60例,对照组采用依达拉奉常规治疗,观察组在对照组基础上加用丁苯酞注射液、胶囊序贯治疗,两组均持续治疗3个月。观察两组患者治疗前后神经功能缺损程度、血液流变学指标、凝血指标、日常生活能力及临床疗效。结果治疗后观察组患者的NIHSS评分、血浆纤维蛋白原(Fib)、全血高切粘度、全血低切粘度及红细胞比容均低于对照组(P<0.05)。观察组患者的Barthel指数及总有效率明显高于对照组(P<0.05)。结论丁苯酞注射液、胶囊序贯疗法联合依达拉奉治疗急性进展性脑梗死可降低患者的神经功能缺损程度、血液流变学指标及凝血指标,提高其日常生活能力及临床疗效。
Objective To observe the effects of butylphthalide injection,capsule sequential therapy combined with edaravone on acute progressive cerebral infarction.Methods 120 cases of patients with acute progressive cerebral infarction admitted to the hospital from February 2016 to February 2018 were selected and divided into observation group and control group according to the random number table method,with 60 cases in each group.Control group was treated with edaravone,and observation group was treated with butylphthalide injection and capsule sequential treatment on the basis of control group,and the two groups were treated for 3 months.The neurological deficit degree,hemorheology indexes,coagulation indexes,daily living ability and clinical efficacy were observed before and after treatment in the two groups.Results After treatment,the NIHSS score,plasma fibrinogen(Fib),whole blood high shear viscosity,whole blood low shear viscosity and hematocrit in observation group were lower than those in control group(P<0.05).The Barthel index and total effective rate in observation group were significantly higher than those in control group(P<0.05).Conclusion Butylphthalide injection,capsule sequential therapy combined with edaravone for acute progressive cerebral infarction can reduce the neurological deficit degree,hemorheology indexes and coagulation indexes,and improve the daily living ability and clinical efficacy.
作者
李艳玲
徐华伟
张东风
Li Yanling;Xu Huawei;Zhang Dongfeng(Department of Neurology,General Hospital of Hebi Coal Industry Group Co.,Ltd,Hebi 458000,China)
出处
《哈尔滨医药》
2019年第6期509-511,共3页
Harbin Medical Journal
关键词
急性进展性脑梗死
丁苯酞
依达拉奉
Acute progressive cerebral infarction
Butylphthalide
Edaravone
