摘要
目的:分析血清胸腺基质淋巴细胞生成素(TSLP)、炎症因子水平与脓毒症患者预后的相关性。方法:回顾性分析2017年1月-2019年1月本院收治的50例脓毒症患者的临床资料,将发病后28 d救治无效死亡的10例患者作为病死组,其余40例患者作为存活组。对比两组脓毒症严重状况、临床指标(TSLP及各类炎症因子)水平,并进行多因素分析。结果:相比存活组,病死组年龄显著大(P<0.05),有意识障碍、脓毒性休克、合并慢性病的患者占比均明显高(P<0.05),急性生理与慢性健康评分(APACHEⅡ)、尿素氮、血乳酸、C反应蛋白(CRP)、降钙素原(PCT)、TSLP水平均显著高(P<0.05);两组性别、吸烟史、饮酒史、白细胞计数、白蛋白(ALB)水平比较,差异均无统计学意义(P>0.05)。Logistic回归分析显示年龄、合并慢性病、APACHEⅡ评分、血乳酸、CRP、PCT、TSLP是脓毒症患者预后不良的独立危险因素(P<0.05)。脓毒症患者预后与血乳酸、CRP、PCT、TSLP均呈负相关(P=0.000)。结论:血清TSLP与CRP、PCT等炎症因子水平与脓毒症患者预后紧密相关,可作为判断病情严重程度的重要指标。
Objective:To analyze the correlation between the levels of serum thymic stromal lymphopoietin(TSLP)and inflammatory factors and prognosis in sepsis patients.Method:The clinical data of 50 sepsis patients who admitted to the hospital from January 2017 to January 2019 were retrospectively analyzed.Ten died patients due to ineffective treatment after 28 d of onset were enrolled as death group,while the remaining 40 patients were enrolled as survival group.The sepsis severity levels of and clinical indexes(TSLP,various inflammatory factors)were compared between the two groups,and multivariate analysis was performed.Result:Compared with the survival group,age was significantly older in the death group(P<0.05),proportion of patients with conscious disorders,septic shock and chronic diseases were significantly higher(P<0.05),score of Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ),the levels of blood urea nitrogen,blood lactic acid,C reactive protein(CRP),procalcitonin(PCT)and TSLP were significantly higher(P<0.05).There were no significant differences in gender,smoking history,drinking history,white blood cell count and albumin(ALB)level between two groups(P>0.05).Logistic regression analysis showed that age,chronic diseases,APACHEⅡscore,blood lactic acid,CRP,PCT and TSLP were independent risk factors of poor prognosis in sepsis patients(P<0.05).The prognosis of sepsis were negatively correlated with blood lactic acid,CRP,PCT and TSLP(P=0.000).Conclusion:The levels of serum TSLP and inflammatory factors such as CRP and PCT are closely related to prognosis of sepsis patients,which can be applied as important indexes to determine disease severity.
作者
罗惠君
张卫星
陈晶莹
何文成
LUO Huijun;ZHANG Weixing;CHEN Jingying;HE Wencheng
出处
《中国医学创新》
CAS
2020年第9期1-4,共4页
Medical Innovation of China
基金
深圳市卫生健康委员会学科建设能力提升项目(201606006)。
