摘要
目的:研究急性脑梗死患者发生神经功能缺损的程度与其体内炎症细胞因子水平的相关性。方法:本研究的对象为2015年5月至2016年6月安庆市立医院神经内科收治的85例急性脑梗死患者和同期在该院进行体检的70例健康人。将其中的急性脑梗死患者纳入脑梗死组,将其中的健康人纳入对照组。根据发生神经功能缺损的程度将脑梗死组患者进一步分为轻型组(患者的神经功能缺损程度评分为4~15分)、中型组(患者的神经功能缺损程度评分为16~30分)和重型组(患者的神经功能缺损程度评分为31~45分)。分别采集各组受检者的血液标本,测定其血液标本中白介素-1β(IL-1β)、白介素-6(IL-6)和肿瘤坏死因子-a(TNF-a)的水平。结果:与对照组受检者相比,脑梗死组患者血清IL-1β、IL-6及TNF-a的水平均较高,差异有统计学意义(P<0.05)。与中型组、轻型组患者相比,重型组患者血清IL-1β、IL-6及TNF-a的水平均较高,差异有统计学意义(P<0.05)。与轻型组患者相比,中型组患者血清IL-1β、IL-6及TNF-a的水平均较高,差异有统计学意义(P<0.05)。结论:随着急性脑梗死患者发生神经功能缺损程度的加重,其血清中IL-1β、IL-6及TNF-a的水平均可逐渐增高。
Objective To investigate the changes and clinical significance of serum interleukin-1β（IL-1β）、interleukin-6（IL-6）、tumor necrosis factor-a（TNF-a） in patients with acute cerebral infarction（ACI）. Methods According to the degree of nervous function defect,85 cases of acute cerebral infarction patients were divided into 3 groups：light-type group,medium-type group and gravis-type group, serum interleukin-1β（IL-1β）、interleukin-6（IL-6）、tumor necrosis factor-a（TNF-a） in acute cerebral infarction were examined by using the method of ELISA（enzyme-linked immuunosorbent assay）. Results Compared with control groud,serum levels of IL-1β、IL-6 and TNF-a in ACI increased significantly（P〈 0.05）.Compared with Light-type group and medium-type group,the serum levels of IL-1β、IL-6 and TNF-a in gravis-type group increased obviously（P〈 0.05）.Conclution IL-1β、IL-6 and TNF-a may participate in the pathogenesis of ACI,and detected their levels may evaluate the severity and prognosis of ACI.
作者
姜伟韬
袁良津
施雪英
Jiang weitao;Yuan liangjin;Shi xueying(department of neurology,anqing municipal hospital,anqing 246003,anhu)
