摘要
目的探讨绝经和年龄对围绝经期妇女血糖的影响,比较年龄和绝经对血糖的作用大小。方法将2008年至2017年在北京世纪坛医院体检科进行体检的40~65岁健康女性1 971人共12 082条体检记录,当成为不同年龄妇女有放回的抽样,按照年龄段分组,研究年龄和绝经是否对血糖有影响。结果绝经妇女的血糖水平高于未绝经妇女的血糖水平,差异有统计学意义[(5.57±1.29)mmol/L vs(5.28±0.92)mmol/L,t′=14.282,P<0.001]。不同年龄组妇女的血糖水平差异显著(F=78.292,P<0.001),进一步作两两比较发现各年龄组妇女的血糖水平都不相同,随着年龄增加,血糖水平也增加。绝经和年龄对血糖水平都有作用。两因素的相加作用只有近2%(R^2=0.020,调整R^2=0.019),年龄贡献的变异(100.275)远大于绝经状况贡献的变异(9.133),前者是后者的近十一倍,年龄对血糖水平的影响/作用比绝经的大。扣除年龄的影响后,绝经妇女患糖尿病的风险增加42.8%(OR=1.428,95%CI:1.030~1.981)。扣除绝经的影响后,年龄仍是影响血糖的重要因素,但与40~48岁组妇女相比,49~52岁组妇女患糖尿病风险并未增加(OR=1.321,95%CI:0.932~1.874),而53~58岁组妇女患糖尿病风险增加75.4%(OR=1.754,95%CI:1.209~2.544),59~65岁组妇女患糖尿病风险则增加近1.5倍(OR=2.454,95%CI:1.687~3.568)。结论绝经及年龄对血糖均有影响,年龄的作用大于绝经对血糖的影响,但绝经和年龄对血糖的共同影响仅占2.0%。
Objective To investigate the effects of menopause and age on blood glucose in premenopausal women.Methods A total of 12 082 physical examination records from 1 971 healthy women aged 40-65 in the physical examination department of Shijitan Hospital from 2008 to 2017 were collected as samples of women of different ages and grouped according to age.Results The blood glucose level in postmenopausal women was statistically higher than that in non-menopausal women [(5.57±1.29) mmol/L vs(5.28±0.92) mmol/L,t′=14.282,P<0.001].There were significant differences in blood glucose levels of women in different age groups(F=78.292,P<0.001).Pairwise comparison showed that the blood glucose level increased with age.Both menopause and age had influences in blood glucose level,but the additive effect of two factors was only about 2%(R^2=0.020,adjusted R^2=0.019).The variation of blood glucose caused by age was much larger than that caused by menopause(100.275 vs 9.133),and the former was nearly 11 times of the latter.After deducting the influence of age,the risk of diabetes in postmenopausal women increased by 42.8%(OR=1.428,95% CI:1.030-1.981),and after deducting the influence of menopause,age was still an important factor affecting blood glucose level.Compared with women in aged 40-48 group,there was no increased risk of diabetes in women aged 49-52 group(OR=1.321,95%CI:0.932-1.874),however,the risk increased by more than 75% in women aged 53-58 group(OR=1.754,95%CI:1.209-2.544) and was nearly 1.5 times of that in women aged 59-65 group(OR=2.454,95%CI:1.687-3.568).Conclusion Menopause and age have influences on blood glucose level,and the effect of age is greater than that of menopause.The combined effect of menopause and age on blood glucose reaches 2.0% only.
作者
贾潇湘
邵素君
白文佩
任正洪
JIA Xiao-xiang;SHAO Su-jun;BAI Wen-pei;REN Zheng-hong(Department of Obstetrics and Gynecology,Beijing Shijitan Hospital of Capital Medical University,Beijing 101100,China;不详)
出处
《中国临床研究》
CAS
2020年第3期308-311,共4页
Chinese Journal of Clinical Research
基金
北京市科技计划项目(2016-2-13)
北京市医院管理中心“登峰”计划专项经费资助(DFL20190701)
北京市属医院科研培育项目(PX2018031)。
关键词
绝经
年龄
血糖
糖尿病
围绝经期
Menopause
Age
Blood glucose
Diabetes
Perimenopausal
