摘要
以ε-己内酯、乙交酯和D,L-丙交酯为单体,丙三醇为起始剂,辛酸亚锡为催化剂,合成了不同分子量的聚酯三元醇。随后将合成的聚酯三元醇引入到聚氨酯(PU)体系中,得到聚氨酯骨胶黏剂。利用核磁共振氢谱和红外光谱表征了聚酯三元醇和聚氨酯胶黏剂的结构。用扫描电子显微镜、万能拉力试验机、差示扫描量热分析仪及恒温震荡箱等研究了不同分子量聚酯三元醇及填料的加入对胶黏剂表面形貌、压缩性能、玻璃化转变温度(Tg)、黏接强度及降解性能的影响。结果表明:含有理论数均分子量为400的聚酯三元醇并添加填料的聚氨酯胶黏剂(PU-6C400-F)显示出较好的综合性能,黏接强度为0.93 MPa,压缩强度与模量分别为12.5 MPa与128.0 MPa,该体系有望取代聚甲基丙烯酸甲酯(PMMA)作为骨胶黏剂使用。
Bone adhesive provides a simple and convenient method for the treatment of bone fractures. It is not necessary to remove of the metal implants. Polyurethane(PU) is a kind of material with good biocompatibility, physical and mechanical properties, and has a wide range of applications in medical fields. A two-component polyurethane adhesive system was designed and its feasibility as a bone adhesive by in vitro experiments was investigated. Briefly, polyester triol was successfully synthesized with ε-caprolactone, glycolide and D, L-lactide as the monomers, glycerol as the initiator and stannous octoate as the catalyst. The synthesized polyurethane triol was then reacted with isocyanate terminated prepolymer to form the polyurethane adhesive. The chemical structure of the polyester triol and PU adhesive were characterized by nuclear magnetic resonance(^1H-NMR) spectroscopy and Fourier transform infrared(FT-IR) spectroscopy. Surface morphology,mechanical properties and thermodynamic properties of polyurethane adhesives were evaluated by scanning electron microscopy(SEM), universal tensile testing machine, and differential scanning calorimetry(DSC). The degradation rate of PU adhesive was tested by placing PU disks in a 10 mL glass vial filled with 0.1 mol/L phosphate buffer saline(PBS) solution at pH 7.4. Effects of polyestertriol molecular weight and the incorporation filler on the properties of PU adhesives were explored. The results showed that the PU-6 C400-F group presented good compressive performance with a bonding strength of 0.93 MPa, and with a compressive strength and modulus of 12.5 MPa and 128.0 MPa, respectively. The PU adhesive could be a good candidate for bone gluing applications.
作者
朱祺
雷昆
郑震
王新灵
肖海军
ZHU Qi;LEI Kun;ZHENG Zhen;WANG Xinling;XIAO Haijun(School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Orthopedics,Fengxian District Central Hospital,Shanghai 201400,China)
出处
《功能高分子学报》
CAS
CSCD
北大核心
2020年第2期194-199,共6页
Journal of Functional Polymers
基金
精准医学创新基金(IFPM2016B005)。
关键词
聚氨酯
骨胶黏剂
力学性能
表面形貌
降解速率
polyurethane
bone adhesive
mechanical property
surface morphology
degradation rate
