摘要
目的探讨中性粒细胞/淋巴细胞比值(NLR)联合尿微量白蛋白/尿肌酐比值(ACR)评估2型糖尿病早期肾损伤的临床价值。方法选取我院2018年1月至2019年5月期间收治的146例2型糖尿病患者,根据是否合并早期肾损伤分为糖尿病组(n=97)和早期糖尿病肾损伤组(n=49),选取同期体检的50例健康人员作为对照组。比较三组的实验室指标,探讨NLR、ACR在2型糖尿病早期肾损伤评估中的价值。结果早期糖尿病肾损伤组、糖尿病组的糖化血红蛋白、空腹血糖、餐后2h血糖、中性粒细胞及尿微量白蛋白均显著高于对照组(P<0.05);早期糖尿病肾损伤组的中性粒细胞、尿微量白蛋白均显著高于糖尿病组(P<0.05)。早期糖尿病肾损伤组的NLR、ACR水平均显著高于糖尿病组及对照组(P<0.05);糖尿病组的NLR、ACR水平与对照组相比,差异无统计学意义(P>0.05)。2型糖尿病早期肾损伤与NLR、ACR水平均呈正相关(r>0, P<0.05)。结论 NLR、ACR均是评估2型糖尿病早期肾损伤的敏感指标,可为疾病的早期诊断及治疗提供重要依据。
Objective To explore the clinical value of NLR combined with ACR in evaluating early renal injury of type 2 diabetes.Methods 146 patients with type 2 diabetes admitted to our hospital from January 2018 to May 2019 were divided into diabetic group(n=97) and early diabetic renal injury group(n=49) according to whether they were complicated with early renal injury, and 50 healthy persons who had physical examination at the same period were selected as the control group. The laboratory indicators of the three groups were compared, and the value of NLR and ACR in the evaluation of early renal injury of type 2 diabetes were explored.Results The glycated hemoglobin, fasting blood glucose, 2 h postprandial blood glucose, neutrophils, and urine microalbumin in the early diabetic renal injury group and the diabetic group were significantly higher than those in the control group(P<0.05);The neutrophils and urine microalbumin in the early diabetic renal injury group were significantly higher than those in the diabetic group(P<0.05). The levels of NLR and ACR in the early diabetic renal injury group were significantly higher than those in the diabetic group and the control group(P<0.05);No significant difference was found in the levels of NLR and ACR between the diabetic group and the control group(P>0.05). Early renal injury of type 2 diabetes was positively correlated with NLR and ACR levels(r>0, P<0.05). Conclusions NLR and ACR are sensitive indicators for evaluating early renal injury of type 2 diabetes, and can provide important evidence for early diagnosis and treatment of the disease.
作者
何枝荣
吴媛
陈鹏飞
HE Zhirong;WU Yuan;CHEN Pengfei(Clinical Laboratory,Guzhen People's Hospital,Zhongshan 528400,China)
出处
《临床医学工程》
2020年第2期173-174,共2页
Clinical Medicine & Engineering
