摘要
目的:研究2型糖尿病患者晨尿和随机尿中白蛋白/肌酐比值(ACR)与24 h尿白蛋白(24 h UA)的相关性,探讨采用随机尿ACR替代24 h UA用于2型糖尿病早期肾损伤筛查的应用价值。方法:收集89例2型糖尿病患者24 h尿及晨尿和随机尿标本,比较晨尿和随机尿ACR与24 h UA的相关性、诊断敏感度及特异度;同时以24 h UA为标准,建立晨尿和随机尿ACR的受试者工作特征曲线(ROC曲线),并比较ROC曲线下面积。结果:晨尿及随机尿ACR分别为9.02及8.65,差异无统计学意义(P>0.05)。随机尿与晨尿ACR呈高度相关关系(r=0.951,P<0.01);晨尿ACR和随机尿ACR与24 h UA亦均呈高度相关关系(P<0.01);晨尿ACR诊断白蛋白尿的敏感度及特异度分别为92.6%及87.5%,随机尿ACR分别为90.1%及87.5%。晨尿和随机尿ACR的ROC曲线下面积分别为0.942±0.020及0.949±0.019(P>0.05)。结论:随机尿ACR具有标本留取简便、与24 h UA相关性较好等特点,可以替代24 h UA作为2型糖尿病早期肾损伤的筛查及监测指标。
Objective：To explore the correlation of the ACR of morning and random urine and 24 hour urinary albumin（24 h UA）,and the application of random urinary ACR replacing 24 h UA in screening the early renal injury of type 2 diabetic patients. Methods：The morning and random urine of 89 type 2 diabetic patients were collected,the diagnostic sensitivity and specificity and correlation of the ACR of morning and random urine and 24 h UA was compared. The curves of ACR and ROC of morning and random urine were established using the standard of 24 h UA,the area under the ROC curve was compared. Results：The ACR of morning and random urine were 9. 02 and 8. 65 mg /mmol,the difference of which was not statistically significant（P〉0. 05）. The ACR in morning urine and random urine was positive correlation（ r = 0. 951,P〈0. 01）,the ACR of morning urine and random urine were greatly positive correlation with 24 h UA（P〈0. 01）. The sensitivity and specificity of the ACR of morning and random urine in screening albuminuria were 92. 6% 90. 1% and 87. 5% 87. 5%,respectively. The areas under ROC curve of the ACR of morning urine and random urine were 0. 942 ± 0. 020 and 0. 949 ± 0. 019,respectively（ P〉0. 05）. Conclusions：The random urine ACR is good correlation with 24 h UA,which can replace 24 h UA in screening and monitoring the early renal injury of type 2 diabetic patients.
出处
《蚌埠医学院学报》
CAS
2014年第8期1110-1112,共3页
Journal of Bengbu Medical College
基金
安徽省阜阳市卫生局医学科研课题资助项目(201327)
关键词
尿液检验
晨尿
白蛋白/肌酐
尿白蛋白
2型糖尿病
肾损伤
urine text
morning urine
the ratio of urine albumin to creatinine
urinary albumin
type 2 diabetes
renal injury
