摘要
目的:探讨舍曲林和艾司西酞普兰对女性抑郁发作患者血清催乳素水平的影响。方法:回顾性分析我院2018年住院的女性首次抑郁发作患者98例,根据用药情况分为舍曲林组(41例)和艾司西酞普兰组(57例),收集基线期和治疗4周末的催乳素水平、汉密尔顿抑郁量表(HAMD-17)和副反应情况;同时选取与研究组相匹配的我院体检数据库中健康青年女性50例为正常对照组。结果:3组催乳素水平在基线期比较无统计学意义(P>0.05),舍曲林组和艾司西酞普兰组治疗4周后均较基线期升高,差异有统计学意义(t=-2.193,-2.444;P<0.05)。治疗4周末,艾司西酞普兰组催乳素水平高于舍曲林组,但无统计学意义(P>0.05);两组高催乳素血症发生率分别为22.81%和14.63%,差异无统计学意义(P>0.05)。结论:舍曲林和艾司西酞普兰可升高女性抑郁发作患者血清催乳素水平。
Objective:To investigate the effects of sertraline and escitalopram on serum prolactin levels in female patients with major depressive disorder.Methods:A retrospective analysis of 98 female patients with major depressive disorder hospitalized in our hospital in 2018 were carried out.They were divided into sertraline group(41 cases)and escitalopram group(57 cases).Prolactin levels,total scores of Hamilton Depression Scale(HAMD-17)and side effects at baseline and 4 th weekend of treatment were collected.At the same time,50 healthy young women in our hospital physical examination database matched with the research group were selected as normal control group.Results:There was no significant difference in prolactin levels between the three groups at baseline(P>0.05).Sertraline group and escitalopram group increased after 4 weeks of treatment compared with baseline(t=-2.193,-2.444;P<0.05).At the 4 th weekend,the level of prolactin in escitalopram group was higher than that in sertraline group,but there was no significant difference(P>0.05);the incidence of hyperprolactinemia in two groups was 22.81%and 14.63%,respectively,with no significant difference(P>0.05).Conclusion:Sertraline and escitalopram can increase serum prolactin levels in female patients with major depressive disorder.
作者
张艳
刘文文
徐玉平
高咏莉
刘胜超
李猛
ZHANG Yan;LIU Wenwen;XU Yuping(Zhengzhou Eighth People's Hospital,Zhengzhou Mental Health Center,Zhengzhou 450000,China)
出处
《中国健康心理学杂志》
2020年第1期1-4,共4页
China Journal of Health Psychology
基金
河南省医学科技攻关计划项目(编号:2018020866)
关键词
舍曲林
艾司西酞普兰
催乳素
女性
抑郁发作
Sertraline
Escitalopram
Prolactin
Women
Major depressive disorder
