摘要
目的 探讨SSRIs类药物舍曲林、艾司西酞普兰及帕罗西汀对抑郁症患者血清催乳素水平的影响,并分析影响催乳素水平变化的相关因素。方法 采用随机数字表法将180例抑郁症患者随机分为三组,分别予舍曲林、艾司西酞普兰和帕罗西汀治疗,观察12周。在基线和12周末测定血清催乳素,分析比较三组血清催乳素变化及高催乳素血症发生率,并将血清催乳素变化数值与药物剂量作相关性分析。结果 治疗12周末,艾司西酞普兰组血清催乳素水平较基线处明显升高(P<0.05),舍曲林组及帕罗西汀组较基线期无明显变化(P>0.05),三组之间血清催乳素水平无明显差异(P>0.05)。三种药物导致高催乳素血症的发生率分别为:舍曲林组7.02%,艾司西酞普兰组28.81%,帕罗西汀组10.34%。三组之间高催乳素血症发生率存在显著性差异(P<0.05),通过Bonferroni校正进行比较发现,艾司西酞普兰组引起高催乳素血症概率高于舍曲林组(P<0.05)和帕罗西汀组(P<0.05)。结论 在临床中,SSRIs可引起高催乳素血症,尤其艾司西酞普兰在升高催乳素和导致高催乳素血症方面更常见。
Objectivee To explore the effects of SSRIs sertraline,escitalopram and paroxetine on serum prolactin level in patients with depression,and analyze the related factors influencing the change of prolactin level.MethodsA total of 180 patients with depression were randomly divided into three groups and treated with sertraline,escitalopram and paroxetine respectively for 12 weeks.Serum prolactin were measured at baseline and at the end of the 12th week.The changes of serum prolactin and the incidence of hyperprolactinemia were analyzed and compared among the three groups,and the correlation between the changes of serum prolactin and drug dose was analyzed.Results After 12 weeks of treatment,serum prolactin levels in the escitalopram group were significantly higher than those at baseline(P<0.05).Sertraline group and paroxetine group had no significant change from baseline(P>0.05).There was no significant difference in serum prolactin number among the three groups(P>0.05).The incidence of hyperprolactinemia induced by the three drugs was 7.02%in sertraline group,28.81%in escitalopram group and 10.34%in paroxetine group,respectively.There were significant differences in the incidence of hyperprolactinemia among the three groups(P<0.05).Bonferroni correction showed that the incidence of hyperprolactinemia in escitalopram group was higher than that in sertraline group(P<0.05)and paroxetine(P<0.05).Conclusion In clinical practice,SSRIs can cause hyperprolactinemia,and escitalopram in particular is more common in increasing prolactin and leading to hyperprolactinemia.
作者
董玲玲
张莉
褚庆文
刘翔
赵黎萍
朱宏伟
DONG lingling;ZHANG li;CHU Qinguen(Baoshan District Mental Heath Center,Shanghai 201999,China)
出处
《国际精神病学杂志》
2023年第2期248-252,共5页
Journal Of International Psychiatry
基金
上海市宝山区科学技术委员会科技创新专项资金项目(编号:19-E-24)
上海交通大学“交大之星”计划医工交叉研究基金(编号:YG2021QN135)。
