摘要
目的比较利培酮和阿立哌唑对精神分裂症患者血脂和血糖代谢的影响。方法选择2013年6月~2015年6月大连市金州区第四人民医院收治的精神分裂症患者175例。根据治疗药物不同,分为利培酮组（n=88）和阿立哌唑组（n=87）。于治疗前和治疗后8周测定两组患者的总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）和空腹血糖（FPG）浓度。结果利培酮组治疗8周后的TG、LDL-C和FPG浓度显著高于治疗前（P〈0.05）。阿立哌唑组治疗8周后的TC、TG、LDL-C、FPG浓度与治疗前差异无统计学意义（P〉0.05）;利培酮组和阿立哌唑组的血糖异常率分别为9.1%和1.1%,血脂异常率分别为10.2%和2.3%,差异有统计学意义（P〈0.05）。结论阿立哌唑对血脂和血糖代谢的影响明显小于利培酮,值得临床推广应用。
Objective To compare the impact of risperidone and aripiprazole on blood lipid and glucose metabolism for patients with schizophrenia.Methods 175 patients with schizophrenia received by the Fourth People′ s Hospital of Jinzhou District in Dalian City from June 2013 to June 2015 were selected.Patients were divided into risperidone group（n =88）and aripiprazole group（n =87）according to different therapy drug.The concentration of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）and fasting blood glucose？（FPG）were tested respectively before treatment and after 8 weeks treatment.Results After 8 weeks treatment,the concentration of TG,LDL-C and FPG in risperidone group was obviously higher than that before treatment（P0.05）.After 8 weeks treatment,the concentration of TG,LDL-C and FPG in aripiprazole group had no statistical significance compared with before treatment（P0.05）.The pathoglycemia rate in risperidone group and aripiprazole group was9.1% and 1.1% respectively,and the dyslipidemia rate was 10.2% and 2.3% respectively,and the difference was statistical significance（P 0.05）.Conclusion The impact of aripiprazole on blood lipid and glucose metabolism is obvious smaller than risperidone,and it is worthy of clinical promotion and application.
出处
《中国当代医药》
2015年第36期84-86,共3页
China Modern Medicine
关键词
精神分裂症
利培酮
阿立哌唑
血脂
血糖
Schizophrenia
Risperidone
Aripiprazole
Blood lipid
Blood glucose
