摘要
目的:探讨苄星青霉素不同用药时机对妊娠合并梅毒感染(PS)患者母婴结局影响。方法:回顾性收集2015年1月-2018年1月本院妇产科收治的PS患者151例,根据苄星青霉素用药时机分为孕早期(<13+6周)用药组(51例),孕中期(14~27+6周)用药组(63例),孕晚期(≥28周)用药组(37例),比较妊娠及新生儿结局并随访活产新生儿,评价治疗后产妇及新生儿甲苯胺红不加热血清试验(TRUST)滴度、新生儿Apgar评分。结果:孕早期组足月分娩率(96.1%)高于孕中期组(84.1%)和孕晚期组(78.4%),早产率(2.0%)低于孕中期组(12.7%)和孕晚期组(16.2%)(均P<0.05);剖宫产率、死胎/死产、流产率3组比较无差异(P>0.05)。孕早期组新生儿1min、5min Apgar评分高于另外两组,新生儿窒息(2.0%)和新生儿先天性梅毒(NCS)(2.0%)发生率低于孕中期组(17.5%、12.7%)和孕晚期组(24.3%、29.7%)(均P<0.05);低体重儿发生率3组无差异(P>0.05)。产妇及新生儿的TRUST阴性率孕早期组(23.5%、54.9%)高于孕中期组(9.5%、23.8%)和孕晚期组(5.4%、21.6%)(P<0.05);婴儿6月龄时,孕早期组新生儿TRUST均转阴,另外两组分别有1例新生儿TRUST阳性,3组转阴率无差异(P>0.05)。结论:苄星青霉素治疗PS疗效较好,尽早诊断并用药有利于改善母婴结局,降低早产及先天性梅毒发生率。
Objective:To explore the influence of benzylpenicillin used in different opportunities for treating pregnant women with syphilis on the maternal and neonatal outcomes of pregnant women with syphilis.Methods:The data of 151 pregnant women with syphilis who had been treated from January 2015 to January 2018 were collected.The women were divided into three groups according to benzylpenicillin used in different opportunities,which include group A(51 cases treated during less than 13+6 gestational weeks),group B(63 cases treated during 14-27+6 gestational weeks),and group C(37 cases treated during≥28 gestational weeks).The maternal and neonatal outcomes were compared among the three groups,and the titer by tolulized red unheated serum test(TRUST)of mothers and newborns were evaluated after treatment.Results:The full term delivery rate of women in group A was 96.1%,which was significant higher than that(84.1%)of women in group B and that(78.4%)of women in group C(P<0.05).The preterm birth rate of women in group A was 2.0%,which was significant lower than that(12.7%)of women in group B and that(16.2%)of women in group C(P<0.05).There were no significant different in rates of cesarean section,stillbirth or still births,and abortion among the three groups(P>0.05).The 1 min and 5 min Apgar scores of neonates in group A were significantly higher than those of neonates in group B and C(P<0.05).The incidence of neonatal asphyxia and neonatal congenital syphilis in group A was 2.0%and 2.0%,which were significant lower than those(17.5%and 12.7%)in group B and those(24.3%and 29.7%)in group C(P<0.05).There was no significant difference in the incidence of low birth weight neonates among the three groups(P>0.05).The maternal and neonatal TRUST negative rate in group A were 23.5%and 54.9%,which were significant higher than those(9.5%and 23.8%)in group B and those(5.4%and 21.6%)in group C(P<0.05).When 6 months old,the TRUST negative rate of neonates in group A,group B,and group C was 100.0%,98.3%,and 97.1%,respectively,which had n
作者
陈春
李彩霞
CHEN Chun;LI Caixia(Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University,Shanxi Province,723000)
出处
《中国计划生育学杂志》
2020年第2期238-242,共5页
Chinese Journal of Family Planning
关键词
妊娠合并梅毒
苄星青霉素
用药时机
母婴结局
Pregnant women with syphilis
Benzylpenicillin
Treatment opportunities
Maternal and neonatal outcomes
