摘要
目的探讨急性脑梗死患者血清低氧诱导因子1α(HIF-1α)、可溶性白细胞分化抗原40配体(sCD40L)、趋化因子CC基序配体3(CCL3)水平与梗死部位、神经功能缺损的相关性。方法选择2015年1月至2018年1月武汉钢铁(集团)公司第二职工医院接诊的80例急性脑梗死患者为研究对象,设为观察组,并选择同期体检健康者65例作为对照组,分析血清HIF-1α、sCD40L、CCL3与梗死部位、神经功能缺损的相关性。结果观察组患者血清HIF-1α、sCD40L、CCL3水平显著高于对照组(P<0.05);皮层下梗死组患者血清HIF-1α、sCD40L、CCL3水平显著高于皮层梗死组患者(P<0.05);重度神经功能缺损患者血清HIF-1α、sCD40L、CCL3水平显著高于轻度、中度神经功能缺损患者(P<0.05);将梗死部位、神经功能缺损作为因变量,将血清HIF-1α、sCD40L、CCL3分别作为自变量,相关性分析结果显示,血清HIF-1α、sCD40L、CCL3和梗死部位、神经功能缺损之间均呈正相关(P<0.05)。结论在急性脑梗死患者中HIF-1α、sCD40L、CCL3的表达和病情严重程度之间存在着密切关系,可促使疾病进展。
Objective To discuss the correlation between serum hypoxia inducible factor 1alpha(HIF-1α),soluble leukocyte differentiation antigen 40 Ligand(sCD40L),chemokine CC motif ligand 3(CCL3)levels and the infarction site and neural dysfunction in patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction treated in our hospital from January 2015 to January 2018 were selected as the observation group,and 65 healthy patients in our hospital were selected as the control group.The correlation between serum HIF-1α,sCD40L,CCL3 and infarct site and neurological dysfunction was analyzed.Results Serum levels of HIF-1α,sCD40L and CCL3 in the observation group were significantly higher than those in the control group(P<0.05).Serum levels of HIF-1α,sCD40L and CCL3 in subcortical infarction group were significantly higher than those in cortical infarction group(P<0.05).Serum levels of HIF1α,sCD40L and CCL3 in patients with severe neurological impairment were significantly higher than those in patients with mild and moderate neurological impairment(P<0.05).When the infarction site and nerve function defect were taken as dependent variables,and serum HIF-1α,sCD40L and CCL3 were taken as independent variables,the correlation analysis results showed that serum HIF-1α,sCD40L and CCL3 were positively correlated with the infarction site and nerve function defect(P<0.05).Conclusions In patients with acute cerebral infarction,there is a close relationship between the expression of HIF-1 alpha,sCD40L and CCL3 and the severity of the disease,which can promote the progression of the disease.
作者
刘美
陈尚超
司志旭
Liu Mei;Chen Shangchao;Si Zhixu(Department of Neurology,the Second Staff Hospital of Wuhan Steel and Iron Group,Wuhan 430085,China)
出处
《神经疾病与精神卫生》
2019年第10期939-942,共4页
Journal of Neuroscience and Mental Health
