摘要
目的探讨血清炎性因子（MMP-9、sC040L）在脑白质疏松症（LA）发病及病情进展中的作用。方法选取LA患者78例（LA组）及同期健康体检者50人（对照组），LA组按照Fazekas评分标准进行严重程度分组：轻度组28例，中度组28例，重度组22例。ELISA法测定血清MMP-9、sCD40L水平；MoCA量表评估认知功能。结果LA组MMP-9、sCD40L水平高于对照组，差异有统计学意义（P〈0．05）。随着疾病进展，不同分级间MMP-9水平逐渐增加，差异有统计学意义（P〈0．05），sCD40L水平差异无统计学意义（P〉0．05）。Pearson相关性分析显示，MMP-9与LA严重程度呈正相关（r=0．497，P=0．004），与MoCA评分呈负相关（r=0．398，P=0．030）；sCD40L与LA严重程度、MoCA评分均无相关性（P〉0．05）。Logistic回归分析显示，MMP-9是LA患者认知功能障碍的独立危险因素（OR=2．336，P=0．014）。结论血清MMP-9、sCD40L参与LA的发病过程，MMP-9可作为评估LA严重程度的指标，与认知功能有关。
Objective To investigate the role oF serum inflammatory factors,matrix metallo proteinase（MMP）-9 and soluble CD40 ligand（sCD40L）,in the pathogenesis and the progression of leukoaraiosis（LA）.Methods A total of 78 cases of LA patients（LA group）and 50 cases of healthy physical examination patients（control group）were selected.LA group was divided into 3 grades according to the Fazekas score：28 cases in mild group,28 in moderate group and 22 in severe group.The levels of serum MMP-9 and sCD40L were measured by enzyme-linked immunosorbent assay（ELIAS）,and the cognitive function was evaluated by the Montreal Cognitive Assessment（MoCA）scale.Results The level of serum MMP-9 and sCD40L of LA group was higher than that of the control group,and the difference was statistically significant（P ~ 0.05）.With the progression of the disease,the level of serum MMP-9 in LA patients increased gradually,and the difference among different grades was statistically significant（P 〈 0.05）.However,there was no significant difference in serum sCD40L among different grades（P〉0.05）.The Pearson correlation analysis showed that the level of serum MMP-9 was positively correlated with the severity of LA（r=0.497,P=0.004）,and negatively correlated with MoCA score（r=-0.398,P=0.030）.There was no significant correlation between the level of serum sCD40L and the severity of LA,the MoCA score（P ：0.05）.Logistic regression analysis showed that MMP-9 was an independent risk factor for cognitive dysfunction in LA patients（0R=2.336,P=0.014）.Conclusions Serum MMP-9 and sCD40L are involved in the pathogenesis of LA,and MMP-9 can be used as an indicator to evaluate the severity of LA,which is related to cognitive function.
作者
陆冰
刘洲
杨宇
陈宵仪
陈秋萍
Lu Bing;Liu Zhou;Yang Yu;Chen Xiaoyi;Chen Qiuping(Geriatrics Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China;Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China)
出处
《神经疾病与精神卫生》
2018年第1期6-9,共4页
Journal of Neuroscience and Mental Health
基金
国家自然科学基金（青年基金项目）（81400986）
“创新强校工程”科研项目（重点培育项目）（4CX14112G）
湛江市科技攻关计划项目（2017801044）
