摘要
目的研究Binswanger病白质病变对胆碱能通路损伤的程度是否与患者认知障碍的程度相关。方法采用Bocti量表(CHIP评分)对41例Binswanger病患者的MR片,选择4个特定的轴位片,对十个解剖部位内损伤胆碱能通路的白质病变程度进行评分。同时采用Mattis痴呆量表(DRS)评价认知障碍程度。对导致胆碱能通路损伤的白质病变MR评分与Mattis痴呆量表进行相关性分析。结果41例患者总的CHIP评分为35.6±13.7,DRS总评分为105.6±18.2,DRS注意力评分为29.5±4.2,DRS记忆评分为11.3±3.2。损伤胆碱能通路的白质病变程度的CHIP评分与Mattis痴呆量表评分有显著相关性(r=-0.43,P<0.05),这种相关性与年龄和受教育程度无关。结论Binswanger病患者认知障碍的程度可能与其白质病变损害胆碱能通路有关。通过CHIP评分可评估Binswanger病白质损伤对胆碱能通路的损害程度。
Objective To investigate the relationship between magnetic resonance imaging(MRI)rating of white matter hyperintensities within cholinergic pathway and dementia in Binswanger's disease.Methods Forty-one patients with Binswanger's disease underwert inspection of MRI.On 4 selected axial images,the severity of WMH in the cholinergic pathways was rated on a 3-point scale for ten regions identified with major anatomical landmarks.The cholinergic pathways hyperintensities scale(CHIPS)were developed by Bocti based immunohistochemical tracings of the cholinergic pathways.Subjects underwent neuropsychological testing with the Mattis dementia rating scale(DRS)to assess cognitive domains of interest(attention,episodic memory,executive functions).Spearman correlation coefficients were used to evalute association between CHIPS score and DRS score.Results The total score of DRS,the score of DRS attention subscale and the score of DRS memory subscale were 105.6±18.2,29.5±4.2 and 11.3±3.2 respectively.The score of CHIPS was 43.6±14.5.After accounting for age and education in a multiple linear regression model,The Cholinergic pathways hyperIntensities scale ratings were associated with impaired performance on the Mattis dementia rating scalec(r =-0.43,P<0.05).Conclusion The MRI rating of white matter hyperintensities within cholinergic pathway has strong correlations with cognitive performance in patients with Binswanger's disease.
出处
《中国卒中杂志》
2006年第10期682-684,共3页
Chinese Journal of Stroke
