摘要
利用多组分1,3-偶极环加成方法,在微波辐射条件下合成一系列螺环结构的目标化合物,对产物进行红外光谱、核磁共振谱、高分辨质谱表征,同时通过X射线单晶衍射分析5-溴-4'-(4-氯苯基)-1'-甲基-3'-(噻吩-2-酰基)螺[吲哚啉-3,2'-吡咯啉]-2-酮的结构。单晶衍射结果表明:该晶体属于单斜晶系,空间群P2(1)/n,晶体参数为a=1.2815(1)nm,b=1.0803(1)nm,c=1.6081(1)nm,α=90°,β=92.728(1)°,γ=90°。在分子晶体结构中,吡咯啉环采用信封式构象,与吲哚啉环通过螺碳原子相连,两个环接近垂直构型,其二面角为88.89(10)°。
The target compounds were synthesized by microwave-assistant one-pot three-component 1,3-dipolar cyclic addition reaction and fully confirmed by IR,1HNMR,13CNMR,HRMS and single X-ray diffraction.The crystal of 5-bromo-4'-(4-chlorophenyl)-1'-methyl-3'-(thiophene-2-carbonyl)spiro[indoline-3,2'-pyrrolidin]-2-one belonged to monoclinic,space group P2(1)/n with a=1.2815(1)nm,b=1.0803(1)nm,c=1.6081(1)nm,α=90°,β=92.728(1)°,γ=90°.In the crystal structure,the pyrrolidin ring adopted envelope configuration,which linked with the indole ring by the spiro-carbon atom.The two planes had almost vertical conformation and the dihedral angle was 88.89(10)°.
作者
於露
徐琳琳
马莹
龚潘伟
朱松磊
YU Lu;XU Lin-lin;MA Ying;GONG Pan-wei;ZHU Song-lei(School of Basic Medical Sciences,Xuzhou Medical University,Xuzhou 221004,China;School of Public Health,Xuzhou Medical University,Xuzhou 221004,China;School of Pharmacy,Xuzhou Medical University,Xuzhou 221004,China)
出处
《化学试剂》
CAS
北大核心
2020年第1期80-85,共6页
Chemical Reagents
基金
徐州市科技计划项目(KC17114)
