摘要
利用多组分1,3偶极环加成反应方法,合成了一种新的螺环结构1'-甲基-3'-吡啶甲酰基-4'-(2-噻吩基)螺[吲哚啉-3,2'-吡咯啉]-2-酮化合物,并对该化合物进行了红外光谱、核磁共振谱及X-射线单晶衍射表征.单晶衍射结果表明:该晶体属于三斜晶系,空间群为P-1,晶体参数为a=0.899 9(1)nm,b=0.914 4(1)nm,c=1.271 1(2)nm,α=92.852(1)°,β=107.305(2)°,γ=101.580(1)°.在分子晶体结构中,吡咯啉环采用了信封式构象,通过螺碳原子与吲哚啉环相连,形成刚性螺环结构,2个环接近垂直构型,其二面角为84.15(2)°.
The new compound,1′-methyl-3′-picolinoyl-4′-（thiophen-2-yl）spiro[indoline-3,2′-pyrrolidin]-2-one,was synthesized by one-pot three-component 1,3-dipolar cyclicaddition reaction and fully characterized by IR,1 H NMR,13 C NMR and single X-ray diffraction.The crystal of the title compound belongs to triclinic,space group P-1with a=0.899 9（1）nm,b=0.914 4（1）nm,c=1.271 1（2）nm,α=92.852（1）°,β=107.305（2）°,γ=101.580（1）°.In the crystal structure,the pyrrolidin ring adopts envelope conformation,which links with the indole ring by the spiro-carbon atom.The two planes have almost vertical configuration with the dihedral angle of 84.15（2）°.
作者
王静
陈艳飞
刘鸿志
闻忍
朱松磊
WANG Jing CHEN Yanqei LIU Hong-zhi WEN Ren ZHU Song-lei(School of Basic Education Sciences, Xuzhou Medical University, Xuzhou 221004, China School of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China)
出处
《分子科学学报》
CSCD
北大核心
2017年第4期320-324,共5页
Journal of Molecular Science
基金
国家级大学生创新创业训练计划项目(201310313017z)
