摘要
目的:探索精神分裂症患者认知功能、血清同型半胱氨酸(Hcy)水平及代谢综合征(MS)间的关系。方法:测量108例奥氮平单药治疗>2年的精神分裂症患者身高、腰围、体质量及血压,并检测其空腹血糖(GLU)、三酰甘油(TG)、高密度脂蛋白(HDL)、血清Hcy水平;根据美国《国家胆固醇教育项目成人治疗组第3次指南》(NCEP-ATPⅢ)MS诊断标准将患者分为MS组(50例)及非MS组(58例);采用重复性神经心理状态测验(RBANS)评估患者的认知功能。结果:MS组体质量指数(BMI)、腰围、血压明显高于非MS组,GLU、TG及Hcy水平显著高于非MS组,HDL显著低于非MS组(P<0.05或P<0.01);RBANS总分与血清Hcy水平呈负相关(r=-0.25,P=0.01)。结论:伴MS精神分裂症患者血清Hcy水平更高,认知功能损害更明显。
Objective:To explore the relationship among the cognitive function,serum homocysteine(Hcy)level and metabolic syndrome(MS)in patients with schizophrenia.Method:The height,waistline,body mass and blood pressure of 108 patients with schizophrenia who had been treated with olanzapine for more than 2 years were measured,and the levels of fasting blood glucose(GLU),triglyceride(TG),high-density lipoprotein(HDL)and serum Hcy were measured.According to the national guidelines for adult treatment in the national cholesterol education program(NCEP-ATPⅢ)diagnostic criteria of MS,the patients were divided into MS group(50 csaes)and non-MS group(58 cases).Cognitive function of the patients was assessed by repeatable battery for the assessment of neuropsychological status(RBANS).Results:The body mass index(BMI),waistline and blood pressure in the MS group were significantly higher than those in non-MS group,the levels of GLU,TG,Hcy and HDL in MS group were significantly higher than those in non-MS group(P<0.05 or P<0.01);and the total score of RBANS was negatively correlated with the level of serum Hcy(r=-0.25,P=0.01).Conclusion:The level of serum Hcy is higher and the impairment of cognitive function is more obvious in schizophrenic patients with MS.
作者
张程赪
王卫平
范卫星
杨致蓉
马春燕
徐菲康
张毅
张晨
ZHANG Cheng-cheng;WANG Wei-ping;FAN Wei-xing;YANG Zhi-rong;MA Chun-yan;XU Fei-kang;ZHANG Yi;ZHANG Chen(the Third Peoples Hospital of Yuebei,Shaoguan 512200,China)
出处
《临床精神医学杂志》
2020年第1期25-27,共3页
Journal of Clinical Psychiatry
基金
国家自然科学基金(81771450、81471358)
金华市科学技术局公益类项目(2018-4-079)
上海市科学技术委员会西医引导类项目(14411969000)
上海市教育委员会高峰高原计划-临床专职研究队伍(20152530)
上海市卫生与计划生育委员会科研项目(201540029)
