摘要
目的探讨首发未服药精神分裂症患者血清同型半胱氨酸(Hcy)水平及其与临床症状之间的关系,进一步探讨精神分裂症发展过程中Hcy所发挥的作用。方法将本院精神科于2018年06月~2020年06月接收的120例首发未服药精神分裂症患者作为研究组,另选取120例正常者作为对照组。利用PANSS(阴性与阳性症状量表)对精神分裂症患者进行症状评估,利用ELISA(酶联免疫吸附试验)测定所有观察对象Hcy水平并进行对比,进一步探讨Hcy与患者病程、年龄、PANSS量表评分以及BMI指数之间的关系。结果研究组Hcy高于对照组(P<0.05);Hcy与阴性症状、PANSS总分呈正性相关(P<0.05)。结论严重的精神病理症状有可能是导致首发未服药精神分裂症患者Hcy水平过高的主要原因。
Objective To explore the relationship between serum homocysteine(Hcy)levels and clinical symptoms in patients with first-episode untreated schizophrenia,and to further explore the role of Hcy in the development of schizophrenia.Methods 120 patients with first-episode unmedicated schizophrenia received from the psychiatric department of our hospital from June 2018 to June 2020 were selected as the research group,and 120 normal patients were selected as the control group.Use the PANSS(negative and positive symptom scale)to evaluate the symptoms of patients with schizophrenia,and use ELISA(enzyme-linked immunosorbent test)to measure and compare the Hcy level of all observation subjects,and further explore the Hcy and the patient’s course,age,and PANSS scale The relationship between score and BMI index.Results Hcy in the study group was higher than that in the control group(P<0.05).Hcy was positively correlated with negative symptoms and PANSS total score(P<0.05).Conclusion Severe psychopathological symptoms may be the main cause of high Hcy levels in first-episode untreated schizophrenia.
作者
赫利寒
蒋芬菲
宋宝山
HE Lihan;JIANG Fenfei;SONG Baoshan(Psychiatry Department,Luoyang Fifth Peopled Hospital,Luoyang 471000,China)
出处
《国际精神病学杂志》
2020年第5期910-912,共3页
Journal Of International Psychiatry
关键词
首发
未服药
精神分裂症
同型半胱氨酸
症状
First episode
No medication
Schizophrenia
Homocysteine
Symptoms
