摘要
目的探讨阿尔茨海默病的精神行为症状(Behavioral and psychological symptoms,BPSD)与血浆同型半胱氨酸(Homocysteine,HCY)水平及颈动脉粥样硬化的关系。方法选取2015年10月~2017年10月我院收治的阿尔茨海默病患者87例,根据阿尔茨海默病患者的神经精神问卷测评结果将其分为两组,BPSD组(n=54)与非BPSD组(n=33)。对患者的血浆HCY进行测定,并采用彩色多普勒检测颈总动脉(Common carotid artery,CCA)与颈内动脉(Internal carotid artery,ICA)内径及内-中膜层厚度(Intima media thickness,IMT),比较两组患者间的差异,并分析血浆HCY水平及颈动脉粥样硬化与BPSD症状的相关性。结果BPSD组患者的血浆HCY水平明显高于非BPSD组患者,且高HCY血症的百分比也明显高于非BPSD组患者,差异均有统计学意义(P<0.05);颈动脉超声结果显示,BPSD组患者的CCA、ICA内径和IMT值均明显高于非BPSD组患者,两组间差异显著(P<0.05)。经多因素Logistic回归分析,血浆HCY水平、CCA颈动脉内径和IMT、ICA颈动脉内径和IMT均是BPSD症状的独立危险因素(OR=3.328、2.824、2.627、2.544和2.417,P<0.05)。结论血浆HCY水平及动脉粥样硬化程度可能与阿尔茨海默病患者的BPSD症状存在一定的相关性。
Objective To investigate the relationships between behavioral and psychological symptoms(BPSD)in Alzheimer's disease and plasma homocysteine(HCY)and carotid atherosclerosis.Methods A total of 87 patients with Alzheimer's disease treated in our hospital from October 2015 to October 2017 were selected and divided into two groups based on the result of psychological survey,the BPSD group(n=54)and the non-BPSD group(n=33).The plasma HCY level was detected and color Doppler was used to detect the internal diameter and intima media thickness(IMT)of the common carotid artery(CCA)and internal carotid artery(ICA).The differences were compared between the two groups.And the relationships between plasma HCY and carotid atherosclerosis and BPSD were analyzed.Results The HCY level was significantly higher in the BPSD group than that in the non-BPSD group,and the percentage of hyperhomocysteinemia was also significantly higher in the BPSD group than that in the non-BPSD group(P<0.05).The internal diameters of CCA and ICA and value of IMT were significantly higher in the BPSD group than those in the non-BPSD group(P<0.05).Multivariate Logistic regression analysis showed that plasma HCY levels,CCA carotid diameter and IMT,ICA carotid diameter and IMT were independent risk factors for BPSD symptoms(OR=3.328,2.824,2.627,2.544,and 2.417,respectively,P<0.05).Conclusion Plasma HCY levels and atherosclerosis may be associated with BPSD symptoms in patients with Alzheimer's disease.
作者
徐哲
夏青春
XU Zhe;XIA Qingchun(Department of Psychiatry,the Third People's Hospital of Huzhou City in Zhejiang Province,Huzhou313000,China)
出处
《中国现代医生》
2019年第35期4-7,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目（2017KY645）
关键词
阿尔茨海默病
神经行为症状
同型半胱氨酸
颈动脉粥样硬化
Alzheimer's disease
Behavioral and psychological symptoms
Homocysteine
Carotid atherosclerosis
