摘要
白细胞介素-34(IL-34)是近年来新发现的一种新型的细胞因子,其受体有巨噬细胞集落刺激因子-1受体、蛋白酪氨酸磷酸酶ξ受体以及多配体蛋白聚糖-1。目前,已知IL-34与集落刺激因子-1的生物学活性相似但不完全相同。研究发现其不仅在各种肿瘤与自身免疫性疾病的发生、发展中发挥重要作用,在细菌、真菌、病毒感染性疾病中也发挥重要作用。因此研究IL-34的各种感染性疾病的作用机制,有助于为各种感染性疾病治疗提供新的方向。此文就IL-34的在感染性疾病中的作用做一综述。
Interleukin 34(IL-34)is a novel cytokine that was identified in recent years,and its receptors include macrophage colony stimulating factor 1 receptor,receptor-like protein-tyrosine phosphatase(RPTP-ξ)and syndecan-1.At present,it is known that IL-34 and colony stimulating factor 1 have similar but not identical biological activities and play an important role in the occurrence and development of various tumors and autoimmune diseases.In addition,it has been found that IL-34 also plays a role in bacterial,fungal and viral infectious diseases.Therefore,studying the mechanism of IL-34 in various infectious diseases is conducive to providing new directions for the diagnosis and treatment of various infectious diseases.This article reviews the biological activity of IL-34 and its role in infectious diseases.
作者
赵方方
贺仁忠
ZHAO Fang-fang;HE Ren-zhong(Department of Respiratory Medicine,the Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou,CHINA)
出处
《海南医学》
CAS
2020年第1期102-105,共4页
Hainan Medical Journal
基金
贵州省科技计划项目(编号：黔科合支撑[2019]2804号)
