摘要
近年来肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)与肿瘤的关系成为研究热点,尤其是肝癌等实体肿瘤。肿瘤微环境中的TAMs释放多种细胞因子和趋化因子介导免疫反应,通过参与上皮细胞间质转化(epithelial-mesenchymaltransitions,EMT),血管生成等过程促进肝癌的侵袭和转移。本文将从TAMs的募集和分化、与肿瘤微环境的关系、促进转移的机制、与肝癌之间的通路以及靶向TAMs治疗肝癌的新方法等方面对TAMs在肝癌中的研究进展进行综述。
The relationships between the tumor-associated macrophage and tumor become a research hotspot in re-cent years, especially hepatocellular carcinoma and other solid tumors. TAMs release multiple cytokines and chemokines mediated immune responses in the tumor microenvironment, they promote the local invasion and distant metastasis by par-ticipating in the epithelial mesenchymal transitions and angiogenesis. This article will discuss TAMs in following aspects：re-cruiment and differentiation,the roles in tumor microenvironment, mechanisms to promote invasion and and metastasis,the pathways linked to HCC and the new treatments targeted TAMs.
出处
《肿瘤预防与治疗》
2014年第4期204-208,共5页
Journal of Cancer Control And Treatment
基金
国家自然科学基金面上项目(NO:81273214)
江苏省高校自然科学研究面上项目(NO:10KJB310017)
江苏省普通高校研究生科研创新计划(NO:CXLX13_924)
关键词
肿瘤相关巨噬细胞
肝细胞癌
血管生成
上皮细胞间质转化
Tumor-associated macrophages
Hepatocellular carcinoma
Angiogenesis
Epithelial-mesenchymaltransition
