摘要
目的探讨慢性萎缩性胃炎(CAG)的危险因素。方法选取2017年1月-2019年2月在华北理工大学附属医院消化科经胃镜及病理诊断为CAG的200例患者作为萎缩组,经胃镜诊断为慢性非萎缩性胃炎的200例患者作为非萎缩组。收集患者性别、年龄、幽门螺旋杆菌(Hp)感染、胆汁反流、嗜烟、饮酒、药物史及家族史等资料进行单因素及多因素回归分析。结果萎缩组平均年龄、男性、Hp阳性、嗜烟、嗜酒、有药物史、有家族史及有冠状动脉粥样硬化性心脏病史比例高于非萎缩组(P<0.05)。多因素回归分析显示,有家族史是CAG的独立危险因素[OR=7.181(95%CI:1.584,32.554)]。CAG不同病理阶段在性别、Hp感染、嗜烟、嗜酒、药物史及家族史等因素比较,差异有统计学意义(P<0.05)。多因素回归分析显示,Hp阳性是CAG病理阶段的独立危险因素[OR=2.538(95%CI:1.459,4.417)]。结论 CAG受多方面因素影响,其中家族史及Hp感染为CAG的危险因素;Hp感染更是CAG病理阶段的独立危险因素。CAG患者根除Hp可获得较多收益。对危险因素进行控制有助于降低CAG风险。
Objective To explore the risk factors of chronic atrophic gastritis. Method From January 2017 to January 2019, patients in North China University of Science and Technology Affiliated Hospital were collected. 200 patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were included in the experimental group(CAG group). 200 patients with non-atrophic gastritis diagnosed by gastroscopy were included in the control group. The data of patients were analyzed retrospectively. The factors include sex, age, Hp infection, bile reflux, smoking, alcohol consumption, drug history, family history and so on were analyzed by univariate and multivariate regression analysis. Result The rates of patients with male, old age, Hp infection, bile reflux, smoking, alcohol consumption, drug history, family history were significantly higher than those of control group(P < 0.05). Multivariate regression analysis showed that familial history was an independent risk factor of CAG group [OR=7.181(95% CI: 1.584, 32.554), P < 0.05]. There were significant differences in sex, Hp infection, smoking, drinking, drug history and family history in different pathological stages of CAG(P < 0.05). Multivariate regression analysis showed that positive Hp was an independent risk factor in CAG pathological stage [OR=2.538(95% CI: 1.459, 4.417)]. Conclusion CAG is affected by many clinical factors, and family history and Hp infection are the risk factors of CAG;and Hp infection is the risk factor of pathological stage of CAG. For CAG patients, the eradication of Hp can bring more benefits. Controlling risk factors helps reduce the risk of CAG.
作者
于思妙
李志婷
Si-miao Yu;Zhi-ting Li(Department of Gastroenterology,North China University of Science and Technology Affiliated Hospital,Tangshan,Hebei 063000,China)
出处
《中国现代医学杂志》
CAS
2020年第2期39-43,共5页
China Journal of Modern Medicine
关键词
胃炎
萎缩性
螺杆菌
幽门
危险因素
治疗结果
gastritis,atrophic
helicobacter pylori
risk factors
treatment outcome
