摘要
目的探讨消癌平注射液联合替吉奥胶囊治疗老年晚期胃癌患者的临床疗效及不良反应。方法收集2014年1月-2017年1月我院收治的80例老年晚期胃癌患者,随机分为观察组和对照组,各40例。观察组给予消癌平注射液联合替吉奥胶囊治疗,对照组给予替吉奥胶囊治疗。持续治疗4个周期,每2个周期进行一次临床疗效评价,比较两组患者的近期疗效、卡氏评分及毒副反应。结果观察组患者治疗有效率(55.0%)显著高于对照组(35.0%)(P<0.05),疾病控制率(77.5%)显著高于对照组(52.5%)(P<0.05)。观察组中位无疾病进展时间(6.2个月)显著长于对照组(3.3个月)(P<0.05),中位生存期(12.1个月)显著长于对照组(7.2个月)(P<0.05)。观察组血清CEA、CA19-9及CA125水平均较治疗前显著降低,并显著低于对照组(P<0.05)。观察组患者生活质量明显优于对照组(P<0.05),消化道反应发生率显著低于对照组(P<0.05)。结论消癌平注射液联合替吉奥胶囊治疗老年晚期胃癌,临床疗效较好,可降低化疗毒副反应,提高患者生活质量,值得临床推广。
Objective To investigate the clinical efficacy and adverse effects of Xiao’aiping injection combined with S-1 capsule in the treatment of elderly patients with advanced gastric cancer.Methods Between January 2014 and January 2017,80 elderly patients with advanced gastric cancer in our department were randomly divided into the observation group and the control group,40 cases in each group.Patients in the observation group were given Xiao’aiping injection combined with S-1 capsule,and patients in the control group were given S-1 capsule.Treatment lasted for four cycles,and clinical efficacy evaluation was conducted after every two cycles of treatment.Compare the recent efficacy,KPS score and adverse reactions between the two groups.Results The overall response rate(ORR)of the observation group(55.0%)was significantly higher than that of the control group(35.0%)(P<0.05).And the disease control rate(DCR)of the observation group(77.5%)was significantly higher than that of the control group(52.5%)(P<0.05).Moreover,the median progression-free survival(mPFS)time was 6.2 months in the observation group,while it was 3.3 months in the control group.The mPFS was obviously longer in observation group than in control group(P<0.05).The median overall survival(OS)was 12.1 months in the observation group and 7.2 months in the control group.The differences were also statistically significant(P<0.05).In addition,the CEA,CA19-9 and CA125 levels in the observation group were lower than those before treatment,and were also lower than those in the control group(P<0.05).After treatment,the patients’quality of life in the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The incidence of gastrointestinal adverse reactions of the observation group was lower than that of the control group(P<0.05).Conclusion The combination of Xiao’aiping injection with S-1 capsule was clinically effective in the treatment of elderly patients with advanced gastric cancer.The regimen
作者
葛亚楠
张冠中
刘兆喆
郑振东
GE Yanan;ZHANG Guanzhong;LIU Zhaozhe;ZHENG Zhendong(Department of Oncology,the General Hospital of the Northern Theater of the Chinese People`s Liberation Army,Shenyang,Liaoning,110016,China)
出处
《肿瘤药学》
CAS
2019年第6期892-896,共5页
Anti-Tumor Pharmacy
基金
辽宁省自然科学基金(20170540966)
关键词
消癌平注射液
替吉奥胶囊
晚期胃癌
老年
Xiao’aiping injection
S-1 capsule
Advanced gastric cancer
The elderly
