摘要
口腔吸入及鼻用制剂(orally inhaled and nasal drug products,OINDPs)是指将药物制备成干粉或雾滴,利用给药装置,分别将药物运送至肺部或鼻腔黏膜,进而发挥局部或全身治疗作用的剂型。喷雾模式和喷雾形态是溶液及混悬型吸入及鼻用制剂体外评价的重要指标,可以采用激光成像系统进行测定。对喷雾模式及喷雾形态的测定方法和结果评价进行了详细讨论,同时对激光成像系统中自动触发器模块的参数选择进行了相关说明。
Orally inhaled and nasal drug products(OINDPs)refers to making drugs into powder or droplets, and delivering drug to the lungs or nasal mucous by using drug delivery device. OINDPs can give play to the role of local or systemic treatment dosage forms. Spray pattern and plume geometry are important indexes for evaluation of solution and suspension inhaled and nasal preparations in vitro, which can be determined by laser imaging system. The measurement methods and result evaluation of spray pattern and plume geometry are discussed in detail, and the parameter selection of automatic trigger module in laser imaging system is explained.
作者
王妍
姜锦秀
胡筱芸
夏俊
李志万
李静
WANG Yan;JIANG Jinxiu;HU Xiaoyun;XIA Jun;LI Zhiwan;LI Jing(Tianjin Pharmaceutial Research Institute Co.,Ltd.,Tianjin 300462,China;Tianjin KingYork Group Co.,Ltd.,Tianjin 300450,China)
出处
《药物评价研究》
CAS
2019年第12期2325-2328,共4页
Drug Evaluation Research
关键词
喷雾模式
喷雾形态
口腔吸入及鼻用制剂
激光成像系统
自动触发器
spray pattern
plume geometry
orally inhaled and nasal drug products
laser imaging system
automatic trigger
