摘要
目的:探讨二黄凝胶贴膏对急性软组织损伤模型大鼠的治疗作用及机制。方法:建立急性软组织损伤模型,每日给药1次,给药3天,进行软组织损伤评分、炎性因子(TNF-α、SOD、MDA)测定、组织病理学观察。结果:与模型组比较,二黄凝胶贴膏0.0015、0.0013g/cm^2能显著降低软组织损伤评分,二黄凝胶贴膏0.0015、0.0013g/cm^2能显著降低肌肉组织中SOD含量,二黄凝胶贴膏0.0015g/cm^2能显著改善组织病变。结论:二黄凝胶贴膏对急性软组织损伤大鼠具有治疗作用,可能通过影响血清及肌肉组织中的SOD来实现。
Objective: To discuss the effect and its mechanism of Erhuang Gel Paste for acute soft tissue injury model rats.Methods: After the acute soft tissue injury model was made,the rats were treated once a day for three days.After treating,the scoring of soft tissue injury,the detection of inflammation cytokines and the pathology observation of tissues were done.Results: Compared with the model group,Erhuang Gel Paste 0.0015,0.0013 g/cm^2 could decrease the soft tissue injury score.Erhuang Gel Paste 0.0015,0.0013 g/cm^2 could decrease the SOD content in muscle tissues.Erhuang Gel Paste 0.0015 g/cm^2 could improve the tissue lesions.Conclusion: Erhuang Gel Paste may treat acute soft tissue injury rats by affecting the SOD content in serum and muscle tissues.
作者
朱力阳
罗杰
马建
涂禾
曾南
ZHU Liyang;LUO Jie;MA Jian(Sichuan Provincial Orthopedic Hospital,Chengdu Sichuan 610041,China;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610041,China)
出处
《四川中医》
2019年第12期38-41,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
国家科技部科研院所技术开发研究专项(编号:2012EG145135)
成都中医药大学科技发展基金(编号:YYZX2018008)
