摘要
目的探讨米力农对急性心力衰竭患者临床疗效及血清炎症因子的影响。方法选取我院心内科于2017年8月至2019年3月收治的急性心力衰竭患者80例,随机分为观察组与对照组,每组40例;对照组采用常规治疗,观察组以对照治疗组为基础,配合米力农注射液治疗;评价临床疗效,评价治疗前后血清氨基末端脑钠肽(NT-proBNP)、内皮素-1(ET-1)、一氧化氮(NO)水平变化及炎症因子水平变化。结果临床疗效研究显示观察组总有效率为87.5%,无效为12.5%;对照组总有效率为70.0%,低于观察组,无效为30%高于对照组,两组数据差异有统计学意义(P<0.05);两组治疗后NT-proBNP、ET-1水平较治疗前均显著下降,NO水平显著升高;治疗后观察组NT-proBNP、ET-1水平低于对照组,而NO水平显著高于对照组,两组治疗后各因子水平差异比较有统计学意义(P<0.05);两组治疗后TNF-α、IL-6、Hs-CRP水平较治疗前均显著下降;治疗后观察组TNF-α、IL-6、Hs-CRP水平显著低于对照组,两组治疗后各因子水平差异比较有统计学意义(P<0.05)。结论米力农对急性心力衰竭治疗效果确切,对恢复心肌收缩力及提高治疗有效率具有积极作用。
Objective To investigate the clinical effect of milrinone on acute heart failure patients and the effect of serum inflammatory factors.Methods 80 patients with acute heart failure admitted to the department of cardiology of our hospital from August 2017 to March 2019 were randomly divided into observation group and control group,with 40 patients in each group.The control group was treated with conventional treatment,while the observation group was treated with milrinon injection on the basis of the control group.Clinical efficacy was evaluated.Changes in serum amino-terminal brain natriuretic peptide(NT-proBNP),endothelin-1(ET-1),nitric oxide(NO)levels and inflammatory factors before and after treatment were evaluated.Results The clinical efficacy study showed that the total effective rate of the observation group was 87.5%,and the invalid rate was 12.5%.The total effective rate of the control group was 70.0%,lower than that of the observation group,and the invalid rate was 30%,higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).The levels of NT-proBNP and ET-1 in the two groups after treatment were significantly lower than that before treatment,and the levels of NO were significantly higher.After treatment,the levels of NT-proBNP and ET-1 in the observation group were lower than those in the control group,while the levels of NO were significantly higher than those in the control group.The levels of TNF-α,IL-6 and Hs-CRP in both groups were significantly lower after treatment than before treatment.After treatment,the levels of TNF-α,IL-6 and Hs-CRP in the observation group were significantly lower than those in the control group,and the difference of factor levels between the two groups after treatment was statistically significant(P<0.05).Conclusion Milrinone is effective in the treatment of acute heart failure and has positive effect on the recovery of myocardial contractility and the improvement of effective rate.
作者
王永军
张积涛
潘振瑞
WANG Yongjun;ZHANG Jitao;PAN Zhenrui(Qingdao Haici Medical Group,Department of Cardiology,Qingdao 266000,China)
出处
《中国老年保健医学》
2019年第6期61-63,共3页
Chinese Journal of Geriatric Care
关键词
急性心力衰竭
氨基末端脑钠肽
米力农
超敏反应蛋白
acute heart failure
Amino terminal brain natriuretic peptide
milrinone
hypersensitive C-reactive protein
