摘要
干细胞被称为医学界的"万能细胞"。随着医学技术的发展,治疗疾病的方法也在日益更新。基于脂肪间充质干细胞具有获取方便,且体外易扩增,伦理学争议小等优点,越来越多的研究人员将目光聚焦在脂肪间充质干细胞上,因此脂肪间充质干细胞在动物模型上的应用也越来越多。本文通过介绍较为典型小鼠疾病模型的临床应用,分析了脂肪间充质干细胞对疾病的治疗作用,得出脂肪间充质干细胞可以通过分泌细胞因子、多向分化,以及免疫调节来发挥多种类型疾病的治疗作用,以期为脂肪间充质干细胞的临床研究与应用提供参考。
Stem cells are known as the "universal cells" in medicine. With the development of medical technology, the method for treating diseases are constantly being updated. Based on the advantages of adipose mesenchymal stem cells(i.e., they are easy to obtain, easy to amplify in vitro, and cause less ethical controversy), an increasing number of researchers focus on this type of stem cells. Therefore, the application of adipose-derived mesenchymal stem cells in animal models is more and more. This article introduces the clinical application of a typical mouse disease model, analyzes the therapeutic effect of adipose-derived mesenchymal stem cells on the disease, and concludes that adipose-derived mesenchymal stem cells can differentiate in many ways by secreting cytokines. Based on clinical research and the application of adipose mesenchymal stem cells, immunomodulation may play a role in the treatment of many kinds of diseases.
作者
杜珍珍
徐郑美
司琳清
曹立明
刘庆
鲁文赓
DU Zhenzhen;XU Zhengmei;SI Linqing;CAO Liming;LIU Qing;LU Wengeng(College of Animal Science and Technology,Heilongjiang Bayi Agricultural University,Daqing 163319,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2019年第6期810-814,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
黑龙江八一农垦大学研究生创新科研项目(YJSCX2018-Y19)~~
关键词
脂肪间充质干细胞
小鼠疾病模型
应用治疗
adipose-derived mesenchymal stem cells
mouse disease model
application therapy
