摘要
目的探讨血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP),同型半胱氨酸(homocystine,Hcy),尿酸检测水平与2型糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的相关性。方法选取2016年9月至2017年9月,东营市第二人民医院收治的2型糖尿病住院患者118例,根据患者神经自主症状以及肌电图检查结果,分为DPN组56例,单纯糖尿病组(SDM组)62例,选取同期健康体检者60例为对照组。分析三组患者神经电生理和血清hs-CRP、Hcy、尿酸指标检测结果及相关性。结果DPN组检测MNTA、MCV、MNFWL、SCV水平低于SDM组和对照组,差异有统计学意义(F=15.252、20.521、17.358、20.479,P=0.013、0.021、0.027、0.032);DPN组检测hs-CRP、Hcy和尿酸水平高于SDM组和对照组,差异有统计学意义(F=21.250、14.221、8.352,P=0.013、0.000、0.040);2型糖尿病患者血清hs-CRP、Hcy和尿酸水平与MNTA、MCV、MNFWL、SCV水平各项数据均存在负相关(P<0.05)。结论血清hs-CRP、Hcy和尿酸为DPN辅助诊断和干预治疗提供可靠的实验室依据。
Objective To explore the correlation between serum levels of hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy),uric acid(UA)and diabetic peripheral neuropathy(DPN)in patients with typeⅡdiabetes mellitus.Methods 118inpatients with typeⅡdiabetes mellitus were divided into DPN group(56cases)and simple diabetes group(62cases)according to the neurological autonomic symptoms and the results of electromyography(EMG),60healthy individuals were also included as controls.Blood samples were collected and serum levels of hs-CRP,Hcy,UA were measured.The Mintab 17statistical software was used to analyze the correlation.Results The levels of MNTA,MCV,MNFWL,SCV in DPN group were lower than that in SDM group and control group(F=15.252,20.521,17.358,20.479,P=0.013,0.021,0.027,0.032),while the serum levels of hs-CRP,Hcy and UA were significantly higher(F=21.250,14.221,8.352,P=0.013,0.000,0.040).The levels of HS-CRP,Hcy and UA were negatively correlated with those of MNTA,MCV,MNFWL and SCV in patients with typeⅡdiabetics(P<0.05).Conclusions Serum hs-CRP,Hcy and UA can be used as serum markers for diagnosis and intervention of DPN.
作者
徐祥坤
孙玉玲
XU Xiang-kun;SUN Yu-ling(The Laboratory Medicine of the Second People′s Hospital of Dongying,Dongying,Shandong 257300,China;不详)
出处
《中国预防医学杂志》
CAS
CSCD
2019年第10期980-983,共4页
Chinese Preventive Medicine
关键词
糖尿病周围神经病变
超敏C反应蛋白
同型半胱氨酸
尿酸
神经电生理检查
Diabetic peripheral neuropathy
Hypersensitive C-reactive protein
Homocysteine
Uric acid
Electrophysiological examination
