期刊文献+

妊娠期糖尿病对新生儿心脏发育的影响 被引量:15

Effects of gestational diabetes mellitus on cardiac development of the newborn
原文传递
导出
摘要 目的探讨母亲妊娠期糖尿病(gestational diabetes mellitus,GDM)对新生儿心脏发育的影响.方法本研究为回顾性分析,选择2016年1~12月首都医科大学附属北京妇产医院新生儿科收治的母亲符合国际糖尿病与妊娠研究组GDM诊断标准的足月新生儿为GDM组;同期收治的非GDM母亲分娩的足月新生儿为对照组.比较两组新生儿出生体重、身长、胎盘重量、出生体重/胎盘重量比值、出生1周内超声心动心脏测量值、先天性心脏病发生率,并对影响GDM组新生儿室间隔肥厚的相关因素进行多元线性回归分析.结果GDM组共纳入104例,对照组共纳入107例.GDM组出生体重、身长和胎盘重量大于对照组,差异有统计学意义(P<0.05);两组性别、胎龄和出生体重/胎盘重量比值差异无统计学意义(P>0.05).GDM组主动脉和主肺动脉宽度,左心房、左心室和右心室大小,室间隔厚度均大于对照组,差异有统计学意义(P<0.05);两组在体重无差异条件下,GDM组室间隔厚度大于对照组[≥3500 g:(3.6±0.5)mm比(3.3±0.3)mm,<3500 g:(3.5±1.0)mm比(3.1±0.4)mm],差异有统计学意义(P<0.05).GDM组先天性心脏病发生率为4.8%(5/104),对照组为0%,两组差异有统计学意义(P<0.05).多元线性回归分析结果显示,GDM组室间隔厚度与母亲孕期糖化血红蛋白、糖化白蛋白、胰岛素水平及新生儿出生体重成正相关(P<0.05).结论母亲GDM对新生儿心肌发育有明显的不良影响,对于其发生机制及如何监控仍需进一步研究. Objective To study the effects of maternal gestational diabetes mellitus(GDM)on neonatal cardiac development.Method From January to December in 2016,full-term neonates of GDM mothers admitted to the neonatal department of our hospital were retrospectively included as the GDM group,and full-term neonates with non-GDM mothers during the same period as the control group.Their birth weight,length,placenta weight,birth weight/placenta weight ratio,echocardiographic cardiac measurements within the first week,and the incidence of congenital heart disease were compared between the two groups.Multivariate linear regression analysis was used to analyse the possible factors causing neonatal ventricular septal hypertrophy in GDM group.Result A total of 104 cases in the GDM group and 107 cases in the control group were included.Significant differences existed in birth weight,length and placental weight between the two groups(P<0.05).No significant differences in gender,gestational age and birth weight/placental weight ratio between the two groups(P>0.05).The width of the aorta and main pulmonary artery,the size of the left atrium,the left ventricle and the right ventricle,and the thickness of the ventricular septum in the GDM group were greater than the control group,the differences were statistically significant(P<0.05).The ventricular septal thickness of the GDM group was greater than the control group[≥3500g:(3.6±0.5)mmvs.(3.3±0.3)mm,<3500g:(3.5±1.0)mmvs.(3.1±0.4)mm],the difference was statistically significant(P<0.05).The incidence of congenital heart disease was 4.8%(5/104)in the GDM group and 0%in the control group.The difference between the two groups was statistically significant(P<0.05).Multivariate linear regression analysis showed that the interventricular septal thickness of the GDM group was positively correlated with the levels of HbA1c,HbA1 c,insulin of their mothers during pregnancy and birth weight of the newborn(P<0.05).Conclusion GDM mother may pose adverse effects on neonatal myocardial development.F
作者 邢继伟 张巍 焦颖 Xing Jiwei;Zhang Wei;Jiao Ying(Department of Neonatology,Capital Medical Uninersity Capital University of Beijing Obstries&Gynecology Hopital,Beijing 100026,China)
出处 《中华新生儿科杂志(中英文)》 CAS 2019年第6期413-417,共5页 Chinese Journal of Neonatology
关键词 糖尿病 妊娠 心肌病 肥厚性 先天性心脏病 婴儿 新生 Diabetes,gestational Cardiomyopathy,hypertrophic Congenital heart disease Infant,newborn
  • 相关文献

参考文献2

二级参考文献29

  • 1董志光,肖温温.妊娠后半期孕妇口服葡萄糖耐量试验的研究[J].中华妇产科杂志,1993,28(3):136-138. 被引量:73
  • 2孙伟杰,杨慧霞.妊娠合并糖代谢异常孕妇的妊娠结局分析[J].中华妇产科杂志,2007,42(6):377-381. 被引量:97
  • 3American Diabetes Association. Diagnosis and classification of diabetes mellitus[ J]. Diabetes Care, 2011,34 : s62-s69. 被引量:1
  • 4妊娠期糖尿病的诊断.中华人民共和国卫生行业标准,WS331-2011. 被引量:2
  • 5O'Sullivan JB, Maban CM, Boston AB. Criteria for the oral glu- cose tolerance test in Pregnancy[ J]. Diabetes, 1964, 13 : 278- 285. 被引量:1
  • 6National Diabetes Data Group. Classification and diagnosis of di- abetes mellitus and other categories glucose intolerance[J]. Di- abetes, 1979, 28: 1039-1057. 被引量:1
  • 7Carpenter MW, Coustan DR. Criteria for screening tests for ges- tational diabetes[J]. Am J Obstet Gynecol, 1982, 144: 768- 773. 被引量:1
  • 8Boyd EM, Donald RC. Summary and recommendations of the fourth international workshop-conference on gestational diabetes mellitus[J]. Diabetes Care, 1998, 21: B161-B167. 被引量:1
  • 9InternationalAssociation of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and preg- nancy study groups recommendations on the diagnosis and classi- fication of hyperglycemia in pregnancy [ J ]. Diabetes Care, 2010, 33: 676-682. 被引量:1
  • 10The HAPO study cooperative research group. Hyperglycemia and adverse pregnancy outcomes [ J]. N Engl J Med, 2008, 358: 1991-2002. 被引量:1

共引文献75

同被引文献139

引证文献15

二级引证文献44

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部