摘要
目的对离舌橐吾Ligularia veitchiana地上部分的化学成分进行研究。方法利用大孔吸附树脂、硅胶柱色谱、半制备高效液相色谱、葡聚糖凝胶等多种色谱方法分离纯化,根据理化性质及波谱数据对化合物进行结构鉴定。结果从离舌橐吾95%乙醇提取物中分离得到16个化合物,分别鉴定为2-hydroxplatyphyllide(1)、ligudentatin A(2)、2-metyoxy-platyphillide(3)、7-hydroxy-11-hydroperoxybisabol-2,9E-diene(4)、bisabola-2,11-diene-7α,10ζ-diol(5)、8β,10β-dihydroxyeremophilenolide(6)、3β(ax)-hydroxyeremophillenolide(7)、6β-hydroxy-8α-ethoxyeremophil-7(11)-en-12,8β-olide(8)、3β,28-dibydroxylup-20(29)-ene(9)、齐墩果酸(10)、3β-hydroxyolean-12-en-27-oic acid(11)、乌苏酸(12)、阿魏酸松柏酯(13)、4-O-geranyl-sinapyl alcohol(14)、4-O-geranyl-coniferyl alcohol(15)、橙皮油素(16)。结论所有化合物均为首次从该植物中分离得到,其中化合物4、5、7、8、11为首次从橐吾属植物中分离得到。
Objective To study the chemical constituents of the aerial parts of Ligularia veitchiana.Methods The isolation and purification were carried out by macroporous resin,silica gel column chromatography,Sephadex LH-20,and semi-preparative HPLC.Their structures were elucidated on the basis of physicochemical properties and spectroscopic data.Results A total of 16 compounds were isolated and elucidated from the aerial parts of Ligularia veitchiana,their structures were identified as:2-hydroxplatyphyllide(1),ligudentatin A(2),2-metyoxy-platyphillide(3),7-hydroxy-11-hydroperoxybisabol-2,9 E-diene(4),bisabola-2,11-diene-7α,10ζ-diol(5),8β,10β-dihydroxyeremophilenolide(6),3β(ax)-hydroxyeremophillenolide(7),6β-hydroxy-8α-ethoxyeremophil-7(11)-en-12,8β-olide(8),3β,28-dibydroxylup-20(29)-ene(9),oleanolic acid(10),3β-hydroxyolean-12-en-27-oic acid(11),ursolic acid(12),coniferyl ferulate(13),4-O-Geranyl-sinapyl alcohol(14),4-O-geranyl-coniferyl alcohol(15),auraptene(16).Conclusion All compounds are isolated from Ligularia veitchiana for the first time.Compounds 4,5,7,8,11 are isolated from the genus Ligularia for the first time.
作者
赵倩倩
王静
王旭阳
曹云刚
ZHAO Qian-qian;WANG Jing;WANG Xu-yang;CAO Yun-gang(College of Food and Biological Engineering,Shaanxi University of Science and Technology,Xi’an 710000,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第21期5212-5216,共5页
Chinese Traditional and Herbal Drugs
基金
陕西省科技厅基金资助项目(2019JQ-252)
陕西省科技厅基金资助项目(2019JQ-453)
国家自然科学基金青年基金项目(31801480)
