摘要
胸腺随着年龄的增长逐渐萎缩,这使老年人机体免疫力降低,患病率增加,生活质量下降。最新研究表明,FOXN1、脂肪、抗氧化酶、多种细胞因子以及激素等因素都与年龄依赖性胸腺萎缩的发生和发展密切相关。全面了解这些因素在胸腺萎缩中发挥的作用及潜在机制,将为逆转及预防胸腺萎缩提供新的思路。本文就近年来年龄依赖性胸腺萎缩的相关因素及其研究做一简要综述。
Thymus gradually atrophy with age,which makes the elderly body immunity decreased,prevalence increased,quality of life decreased.Recent studies have shown that FOXN1,fat,antioxidant enzymes,various cytokines and hormones are closely related to the occurrence and development of age-related thymus atrophy.A comprehensive understanding of the roles and potential mechanisms of these factors in thymus atrophy will provide new ideas for reversing and preventing thymus atrophy.We reviews the related factors and research of age-dependent thymic atrophy in this paper.
作者
曾艳
宋银宏
ZENG Yan;SONG Yin-Hong(Department of Etiology and Immunology,Medical College of China Three Gorges University,Institute of Infection and Inflammation,China Three Gorges University,Yichang 443002,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第23期2932-2935,共4页
Chinese Journal of Immunology
基金
国家自然科学基金(81671397)
湖北省宜昌市科技局项目(A16-301-32)资助
关键词
年龄
胸腺萎缩
相关因素
Age
Thymic atrophy
Related factors
