摘要
目的通过芦荟多糖对衰老模型小鼠的影响,观察小鼠胸腺组织结构的改变,以增进对衰老免疫学机制的了解,探求芦荟多糖对免疫衰老调节的理论及实验依据。方法选取3周龄健康雌性NIH(National Institutes of Health)小鼠[此种小鼠由美国国家卫生研究院(NIH,National Institutes of Health)培育而成,故名]4只,体重20±4 g,按体重随机分为4组:衰老模型组、芦荟多糖组、抗衰老阳性对照组(灵芝多糖组)、正常对照组。连续灌胃30天后,取小鼠胸腺组织切片HE染色观察,检测小鼠胸腺组织结构的变化。结果芦荟多糖组胸腺皮质增厚,皮髓质分界明显,淋巴细胞密集,细胞结构清晰,形态规则,与正常组、抗衰老阳性对照组(灵芝多糖组)比较差异无显著性。证明芦荟多糖可阻止胸腺淋巴细胞的衰老性减少,抑制胸腺组织的脂肪化。结论芦荟多糖可通过阻止胸腺的萎缩与退化发挥抗衰老作用。
Objective By observing the effects of Aloe Polysaccharide on the model of aged mice and the change of thymie tissue so as to gain more insight into immunological mechanism of aging and study the theoretical and experimental evidence for exploring the regulation of Aloe Polysaccharide on aging. Methods Forty four three-week and 20 ± 4 g NIH （National Institutes of Health） femal mice were randomly divided into 4 groups： aged model group, Aloe group, antiaging positive control group, normal control group. Aloe polysaccharide was supplemented daily to mice （100 mg/kg body weight per day）. After 30 days,The effects of Aloe polysaccharide on thymic tissue of mice were investigated with HE method. Results The thymic cortex of Aloe group became thick. The thymic cortex and medulla was clearly to mark out. Lymphosytes were highly concentrated. Its shape was nomal and the same as normal control group. It showed that Aloe polysaccharide supplemented daily could inhibit the lower number of thymic lymphycyte because of aging. Conclusion Aloe Polysaccharide has antiaging effect by delaying the atrophy of thymus of aged mice.
出处
《中南医学科学杂志》
CAS
2011年第6期626-628,共3页
Medical Science Journal of Central South China
基金
湘潭科技局科研立项课题(JZ200807)
关键词
芦荟多糖
免疫衰老
胸腺组织
aloe polysaccharide
immunosenescence
thymic tissue
